Factors independently associated with odds of fractures

Slides:

Advertisements

Similar presentations

Time line of data collection in the Nurses’ Health Study, 1988 to 2000 A. Heather Eliassen et al, Arch Intern Med. 2005; 165:

Advertisements

Hazard of incident coronary heart disease by diabetes status, with or without elevation of troponin T No diabetes Pre- diabetes Diabetes No diabetes Pre-

Blood samples available from study participants with myocardial infarction and controls by ethnic origin Matthew J McQueen, et al. Lancet 2008; 372:

Pai JK et al. N Engl J Med 2004; 351: Relative CHD risk by increasing baseline CRP plasma levels,* relative to CRP

Solomon Tesfaye et al N Engl J Med 2005;352: Comparison of Baseline Data in 1819 Patients According to Whether There Was an Assessment for Neuropathy.

The Heart Outcomes Prevention Evaluation (HOPE) 2 Investigators. N Engl J Med 2006; available at: End pointActive therapy PlaceboRelative.

以多重死因資料比較台灣美國腦中風併發吸入性肺炎之趨勢奇美醫學中心張嘉祐醫師. Stroke Statistics -- A Report From the American Heart Association Approximately 56% of stroke deaths in 2009.

Date of download: 7/10/2016 Copyright © The American College of Cardiology. All rights reserved. From: Healthy Lifestyle and Decreasing Risk of Heart Failure.

Copyright © 2011 American Medical Association. All rights reserved.

Baseline Characteristics of Women and Men in Whom Coronary Heart Disease Developed during Follow-up and Matched Controls - A Jennifer K. Pai et al. N.

Alcohol, Other Drugs, and Health: Current Evidence March–April 2017

Copyright © 2009 American Medical Association. All rights reserved.

Copyright © 2009 American Medical Association. All rights reserved.

No evidence that AF type significantly impacts stroke risk

Odds ratios for change in PD from earliest mammogram within levels of earliest PD. No evidence for an interaction of earliest PD and change in PD on breast.

Relationship of Physical Activity and Body Mass Index to the Risk of Hypertension: A Prospective Study in Finland by Gang Hu, Noël C. Barengo, Jaakko Tuomilehto,

Associations of renal impairment (adjusted odds ratio and 95% CI) and the presence of individual small vessel disease markers stratified by age. Associations.

Body Mass Index and Heart Failure Among Patients With Type 2 Diabetes MellitusCLINICAL PERSPECTIVE by Weiqin Li, Peter T. Katzmarzyk, Ronald Horswell,

Adjusted mortality risk

WHI Observational Study: Cardiovascular death in women with hypertension but no history of CVD on monotherapy CVD death Diuretic, HR (95% CI) ACE inhibitor,

Coagulation factors IX through XIII and the risk of future venous thrombosis: the Longitudinal Investigation of Thromboembolism Etiology by Mary Cushman,

Prevalence of statin and beta-blocker use by clinical presentation

Odds Ratio Interpretation Confounder  Diabetes

Sleep Duration and Blood Pressure

Drug Rate ratio 95% CI Thiazide diuretics 1.0 Reference ACE inhibitors

PREMIER: Rate of hypertension at 18 months

Nat. Rev. Cardiol. doi: /nrcardio

Creatinine clearance in cases and controls

Survival in chronic hypersensitivity pneumonitis (CHP) patients receiving immunosuppressive therapy. a) 5-year survival based on use of immunosuppressive.

Impact of risk factors and age of initiation of therapy on the distribution of lifespan gain. ‘National average risk’ refers to a cohort beginning at age.

Dileep Raman et al. JACEP 2017;3:

Adjusted odds ratio for hypoglycemia with gatifloxacin and levofloxacin compared with macrolide antibiotics Antibiotic Odds ratio of hypoglycemia 95% CI.

Wesley T. O’Neal et al. JACEP 2016;2:

Relative risk reduction for incident hypertension associated with weight loss of 6.8 kg: The Framingham Study Cohort Risk reduction (%) Relative risk.

Forest plot of risk ratio with its 95% CI for the incidence of contrast-induced nephropathy among patient taking statin versus control based on renal impairment.

Cystatin C levels and risk of death from all causes

Risk for BMI outcome (%)

Baseline Characteristics of Cardiovascular Risk Factors and Selected Dietary Variables in a Cohort of 22,881 Men and 35,091 Women to Quintile of Fish Intakes.

Patient characteristics: American vs Canadian transplant patients

Connie W. Tsao et al. JCHF 2016;4:

A.V. Khera et al. N Engl J Med 2011;364:127-35

Baseline Demographic Characteristics of Adults With Diagnosed Heart Failure and Eligible to Receive Lipid-Lowering Therapy Alan S. Go, et al.

Characteristics of Participants in the Nurses Health Study According to Alcohol Intake Meir J.Stampfer et al N Engl J Med 2005;352:

Trends and inequities in beta-blocker prescribing for heart failure

Persistent organic pollutants and diabetes - Spearman correlation coefficients* among six POPs with age, sex, race and ethnicity, poverty income.

Long-term risk for ever being overweight or more or obese

A Single Participant Exposed Twice to an Inflammatory Stimulus

Connie W. Tsao et al. JCHF 2016;4:

Associations between type of MI and incident HF

Genetic predisposition to CHD modifies the increased CHD risk associated with smoking (*) ORs adjusted for age, gender, total energy intake, alcohol intake,

Number of patients who would have benefitted from addition of ACE inhibitor (ACEi), beta blockers (BB) or optimal therapy (one or both of ACEi and BB)

Lifetime heart failure risk*

The risk of graft failure is highest for sex mismatched donors and recipients when the recipient body surface area is greater than the donor. The risk.

Benefit from Earlier Intervention

Risk factors Odds ratio 95% CI p Age >75 (referent: age 46-60) 2.17

ORs for presence of the metabolic syndrome (95% CI) at age 43 years according to leisure-time physical activity and TV viewing (adjusted for sex, socioeconomic.

Increase of physical activity over time associated with lower HF risk

Odds ratios for development of type 2 diabetes in 8,633 healthy men, adjusted for age, examination year, BMI, smoking habit, alcohol intake, parental history.

Orly Vardeny et al. JCHF 2016;4:

Risk of cardiovascular disease mortality by cardiorespiratory fitness and body mass index categories, 2316 men with type 2 diabetes at baseline, 179 deaths.

Risk of type 2 diabetes as a function of ABCA1 and ABCG1 genotype in CCHS. Hazard ratios were multifactorially adjusted for age, sex, BMI, hypertension,

Adjusted cumulative incidence of stroke, by sex and heart failure status. Adjusted cumulative incidence of stroke, by sex and heart failure status. The.

Associations of dialysis session length with mortality and hospitalizations. Associations of dialysis session length with mortality and hospitalizations.

Risk of mortality in patients with diabetes and ESRD

Adjusted ORs of increasing severity of heartburn at follow-up in reference to baseline from model adjusted for BMI category, CVD history, BDI score >11,

The cumulative incidence curve demonstrated that patients with a sub-optimal LDL-C response to statin therapy were associated with a higher risk of CVD.

The risk of graft failure is highest for sex mismatched donors and recipients when the recipient weight is greater than the donor. The risk of graft failure.

The CHA(2)DS2-(VASc) stroke risk and HAS-BLED bleeding risk index are calculated by totalling the scores for each risk factor present.68–71 The lower graph.

Adjusted cumulative disability incidence by sex and heart failure status. Adjusted cumulative disability incidence by sex and heart failure status. The.

Presentation transcript:

Factors independently associated with odds of fractures Adjusted odds ratio (95% CI) No warfarin Reference group <1-y warfarin therapy 1.03 (0.82-1.29) >1-y warfarin therapy 1.25 (1.06-1.48) Men (>1-y warfarin therapy) 1.63 (1.26-2.10) Women (>1-y warfarin therapy) 1.05 (0.88-1.26) Warfarin use on discharge* 0.95 (0.81-1.11) Age (10-year increase) 1.63 (1.47-1.80) African American race 0.30 (0.18-0.51) *Forced into model to prevent confounding Gage BF et al. Arch Intern Med 2006; 166:241-246. Long-term use of warfarin increases risk of fracture in men [Rheumawire > News; Jan 27, 2006

Factors independently associated with odds of fractures Adjusted odds ratio (95% CI) No warfarin Reference group Male sex 0.54 (0.46-0.62) Beta-blocker use 0.84 (0.70-1.00) Heart failure 0.86 (0.75-0.98) High fall risk 1.78 (1.42-2.21) Hyperthyroidism 1.77 (1.16-2.70) Neuropsychiatric impairment 1.51 (1.28-1.78) Alcoholism 1.50 (1.01-2.24) Corticosteroid use* 1.24 (0.97-1.58) *Forced into model to prevent confounding Gage BF et al. Arch Intern Med 2006; 166:241-246. Long-term use of warfarin increases risk of fracture in men [Rheumawire > News; Jan 27, 2006