Melatonin Lulling Th17 Cells to Sleep

Slides:

Advertisements

Similar presentations

Aurora Kinases and Protein Phosphatase 1 Mediate Chromosome Congression through Regulation of CENP-E Yumi Kim, Andrew J. Holland, Weijie Lan, Don W. Cleveland.

Advertisements

SOD1 Integrates Signals from Oxygen and Glucose to Repress Respiration Amit R. Reddi, Valeria C. Culotta Cell Volume 152, Issue 1, Pages (January.

Individualized Medicine from Prewomb to Tomb Eric J. Topol Cell Volume 157, Issue 1, Pages (March 2014) DOI: /j.cell Copyright.

The RAG Recombinase Dictates Functional Heterogeneity and Cellular Fitness in Natural Killer Cells Jenny M. Karo, David G. Schatz, Joseph C. Sun Cell Volume.

The Cell-Non-Autonomous Nature of Electron Transport Chain-Mediated Longevity Jenni Durieux, Suzanne Wolff, Andrew Dillin Cell Volume 144, Issue 1, Pages.

T-bet+ Treg Cells Undergo Abortive Th1 Cell Differentiation due to Impaired Expression of IL-12 Receptor β2 Meghan A. Koch, Kerri R. Thomas, Nikole R.

What We Talk About When We Talk About Fat Evan D. Rosen, Bruce M. Spiegelman Cell Volume 156, Issue 1, Pages (January 2014) DOI: /j.cell

Treatment of Obesity with Celastrol

Transcriptional Control of Gene Expression by MicroRNAs Basel Khraiwesh, M. Asif Arif, Gotelinde I. Seumel, Stephan Ossowski, Detlef Weigel, Ralf Reski,

Common Sense about Taste: From Mammals to Insects David A. Yarmolinsky, Charles S. Zuker, Nicholas J.P. Ryba Cell Volume 139, Issue 2, Pages (October.

UvrD Helicase Unwinds DNA One Base Pair at a Time by a Two-Part Power Stroke Jae Young Lee, Wei Yang Cell Volume 127, Issue 7, Pages (December.

Nucleation and Transport Organize Microtubules in Metaphase Spindles Jan Brugués, Valeria Nuzzo, Eric Mazur, Daniel J. Needleman Cell Volume 149, Issue.

Eph-Ephrin Bidirectional Signaling in Physiology and Disease Elena B. Pasquale Cell Volume 133, Issue 1, Pages (April 2008) DOI: /j.cell

Xenobiotics Shape the Physiology and Gene Expression of the Active Human Gut Microbiome Corinne Ferrier Maurice, Henry Joseph Haiser, Peter James Turnbaugh.

GDE2 Regulates Subtype-Specific Motor Neuron Generation through Inhibition of Notch Signaling Priyanka Sabharwal, Changhee Lee, Sungjin Park, Meenakshi.

Structurally Distinct Ca2+ Signaling Domains of Sperm Flagella Orchestrate Tyrosine Phosphorylation and Motility Jean-Ju Chung, Sang-Hee Shim, Robert A.

Neuronal Cell Types and Connectivity: Lessons from the Retina H. Sebastian Seung, Uygar Sümbül Neuron Volume 83, Issue 6, Pages (September 2014)

Nuclear Receptors, RXR, and the Big Bang Ronald M. Evans, David J. Mangelsdorf Cell Volume 157, Issue 1, Pages (March 2014) DOI: /j.cell

Transmembrane Receptor DCC Associates with Protein Synthesis Machinery and Regulates Translation Joseph Tcherkezian, Perry A. Brittis, Franziska Thomas,

The Landscape of Microsatellite Instability in Colorectal and Endometrial Cancer Genomes Tae-Min Kim, Peter W. Laird, Peter J. Park Cell Volume 155, Issue.

The Good Fat Cell Volume 147, Issue 7, (December 2011) DOI: /j.cell Copyright © 2011 Terms and Conditions Terms and Conditions.

SRC-3 Coactivator Functional Lifetime Is Regulated by a Phospho-Dependent Ubiquitin Time Clock Ray-Chang Wu, Qin Feng, David M. Lonard, Bert W. O'Malley.

Myc Represses Primitive Endoderm Differentiation in Pluripotent Stem Cells Keriayn N. Smith, Amar M. Singh, Stephen Dalton Cell Stem Cell Volume 7, Issue.

Volume 1, Issue 1, Pages (June 2007)

Nomeda Girnius, Roger J. Davis Cancer Cell

Unweaving the Autism Spectrum

Suppressing NFAT Increases VEGF Signaling in Hemangiomas

Checks and Balances: IL-23 in the Intestine

Volume 159, Issue 5, Pages (November 2014)

Should I Stay or Should I Go: Neuromodulators of Behavioral States

Unraveling the Pros and Cons of Interferon-γ Gene Regulation

In This Issue Cell Volume 158, Issue 5, (August 2014)

Volume 46, Issue 5, Pages (June 2012)

Computing at the Front-End by Receptor Networks

The Importance of Timing

Nutrient Competition: A New Axis of Tumor Immunosuppression

At the Intersection of Plant Growth and Immunity

Axis Formation— β-Catenin Catches a Wnt

Volume 152, Issue 1, (January 2013)

Stress Flips a Chromatin Switch to Wake Up Latent Virus

MicroRNAs: From Decay to Decoy

Volume 130, Issue 6, (September 2007)

The RAS/MAPK Axis Gets Stressed Out

Singular Expression of Olfactory Receptor Genes

NOTCH and PI3K-AKT Pathways Intertwined

Proteins Kinases: Chromatin-Associated Enzymes?

Easy Stress Relief by EZH2

Hard Times for Oncogenic BRAF-Expressing Melanoma Cells

Volume 143, Issue 6, (December 2010)

Making the Most from Changes in Life

Volume 14, Issue 4, Pages (October 2008)

Ethylene Prunes Translation

Cytokine Signaling Modules in Inflammatory Responses

Hippo Signaling Goes Long Range

Crosstalk in Cellular Signaling: Background Noise or the Real Thing?

Releasing the Brakes on Cancer Immunotherapy

Cell Migration: GSK3β Steers the Cytoskeleton's Tip

Volume 163, Issue 4, (November 2015)

All Roads Lead to the Ribosome

Volume 13, Issue 2, Pages (August 2013)

Taking LSD1 to a New High Cell

Volume 163, Issue 2, (October 2015)

At 17, In-10's Passion Need Not Inflame

Flies Sleep on It, or Fuhgeddaboudit!

Volume 134, Issue 6, (September 2008)

Volume 63, Issue 6, Pages (September 2016)

Marking Emerging β- and γδ-Selected T Cells

In This Issue Cell Volume 145, Issue 3, (April 2011)

Volume 148, Issue 1, (January 2012)

Targeting Protein Stability with a Small Molecule

Presentation transcript:

Melatonin Lulling Th17 Cells to Sleep Jacob S. Lee, Daniel J. Cua Cell Volume 162, Issue 6, Pages 1212-1214 (September 2015) DOI: 10.1016/j.cell.2015.08.054 Copyright © 2015 Elsevier Inc. Terms and Conditions

Figure 1 Melatonin Shifts the Balance from Th17 to Tr1 (A) Depicted is a schematic of the melatonin signaling pathway resulting in the inhibition of Rorc. (1) Melatonin signals through the melatonin receptor MTNR1A and results in ERK 1/2 phosphorylation. (2) Phosphorylated ERK 1/2 activates the transcription factor C/EBPα (3) and represses the expression of Nr1d1 (REV-ERBα). (4) NR1D1 represses the transcription of Nfil3, which is a (5) repressor of Rorc. Thus, melatonin signaling releases the inhibition of Nfil3 by NR1D1 and results in the suppression of Rorc. (B) A representation of various environmental cues regulating the balance between proinflammatory Th17 cells and immunosuppressive Treg/Tr1 cells. Cell 2015 162, 1212-1214DOI: (10.1016/j.cell.2015.08.054) Copyright © 2015 Elsevier Inc. Terms and Conditions