Studies of hypoxemic/reoxygenation injury with aortic clamping

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Presentation transcript:

Studies of hypoxemic/reoxygenation injury with aortic clamping Kai Ihnken, MD, Kiyozo Morita, MD, Gerald D. Buckberg, MD, Helen H. Young, PhD The Journal of Thoracic and Cardiovascular Surgery Volume 110, Issue 4, Pages 1255-1264 (October 1995) DOI: 10.1016/S0022-5223(95)70012-9 Copyright © 1995 Mosby, Inc. Terms and Conditions

Fig. 1 Percent recovery of LV Ees after abrupt or gradual reoxygenation without blood cardioplegia (see text for description). The Journal of Thoracic and Cardiovascular Surgery 1995 110, 1255-1264DOI: (10.1016/S0022-5223(95)70012-9) Copyright © 1995 Mosby, Inc. Terms and Conditions

Fig. 2 Percent recovery of LV Ees in nonhypoxemic piglets undergoing hyperoxemic blood cardioplegia (Po 2) about 400 mm Hg and after reoxygenation of hypoxemic piglets with either normoxemic (Po 2 about 100 mm Hg) or hyperoxemic (Po 2 about 400 mm Hg) blood cardioplegic solution (see text for description). The Journal of Thoracic and Cardiovascular Surgery 1995 110, 1255-1264DOI: (10.1016/S0022-5223(95)70012-9) Copyright © 1995 Mosby, Inc. Terms and Conditions

Fig. 3 Myocardial CD production during cardioplegic induction and reperfusion in control piglets undergoing hyperoxemic (Po 2 400 mm Hg ) CPB and blood cardioplegia and in hypoxemic piglets reoxygenated with either normoxemic (Po 2 100 mm Hg) or hyperoxemic (Po 2 400 mm Hg) blood cardioplegic solution (see text for description). The Journal of Thoracic and Cardiovascular Surgery 1995 110, 1255-1264DOI: (10.1016/S0022-5223(95)70012-9) Copyright © 1995 Mosby, Inc. Terms and Conditions

Fig. 3 Myocardial CD production during cardioplegic induction and reperfusion in control piglets undergoing hyperoxemic (Po 2 400 mm Hg ) CPB and blood cardioplegia and in hypoxemic piglets reoxygenated with either normoxemic (Po 2 100 mm Hg) or hyperoxemic (Po 2 400 mm Hg) blood cardioplegic solution (see text for description). The Journal of Thoracic and Cardiovascular Surgery 1995 110, 1255-1264DOI: (10.1016/S0022-5223(95)70012-9) Copyright © 1995 Mosby, Inc. Terms and Conditions

Fig. 4 CD concentration in coronary sinus blood sampled during hypoxemia and reoxygenation with cardioplegia (BCP) on CPB. Control piglets did not undergo hypoxemia or reoxygenation, and hypoxemic piglets were reoxygenated with either normoxemic (Po 2 100mm Hg) or hyperoxemic (Po 2 400 mm Hg) blood cardioplegic solution (see text for description). The Journal of Thoracic and Cardiovascular Surgery 1995 110, 1255-1264DOI: (10.1016/S0022-5223(95)70012-9) Copyright © 1995 Mosby, Inc. Terms and Conditions

Fig. 5 Myocardial antioxidant reserve capacity in control piglets undergoing hyperoxemic CPB and blood cardioplegia without hypoxemia (control) and hypoxemic piglets undergoing reoxygenation with either hyperoxemic (Po 2 400 mm Hg), or normoxemic (Po 2 100 mm Hg) blood cardioplegic solution (see text for description). The Journal of Thoracic and Cardiovascular Surgery 1995 110, 1255-1264DOI: (10.1016/S0022-5223(95)70012-9) Copyright © 1995 Mosby, Inc. Terms and Conditions