Low-dose mifepristone increases uterine natural killer cell cytotoxicity and perforin expression during the receptive phase Feng Zhou, M.M., Xiu-Ying Chen, M.M., Ya-Ling Zhuang, M.D., Yue-Zhou Chen, M.D., Li-Li Huang, M.D. Fertility and Sterility Volume 96, Issue 3, Pages 649-653 (September 2011) DOI: 10.1016/j.fertnstert.2011.06.074 Copyright © 2011 American Society for Reproductive Medicine Terms and Conditions
Figure 1 Morphological characteristics of endometrium before and after culture with mifepristone. Sections of endometrial explants were stained with hematoxylin and eosin (H & E) before culture (A), or after 24 hours in culture with 0 (B), 65 (C), and 200 nmol/L mifepristone (D). Magnification, ×200. Fertility and Sterility 2011 96, 649-653DOI: (10.1016/j.fertnstert.2011.06.074) Copyright © 2011 American Society for Reproductive Medicine Terms and Conditions
Figure 2 Comparative analysis of the effects of mifepristone on expression of perforin by uterine natural killer cells during the receptive phase. Perforin (black) expression was localized in the cytoplasm and CD56 (red) expression was localized on the cell membrane of endometrial explants after 24 hours in culture with 0 (A), 65 (B), and 200 nmol/L mifepristone (C). Cells double-labeled with antibodies against perforin and CD56 are indicated with white arrows. Magnification, ×400. Fertility and Sterility 2011 96, 649-653DOI: (10.1016/j.fertnstert.2011.06.074) Copyright © 2011 American Society for Reproductive Medicine Terms and Conditions