Low-dose mifepristone increases uterine natural killer cell cytotoxicity and perforin expression during the receptive phase Feng Zhou, M.M., Xiu-Ying.

Slides:

Advertisements

Similar presentations

Molecular characterization of uterine fibroids and its implication for underlying mechanisms of pathogenesis Paul J. Hoffman, B.S., Dawn B. Milliken,

Advertisements

Glycodelin is present in pinopodes of receptive-phase human endometrium and is associated with down-regulation of progesterone receptor B Anneli Stavreus-Evers,

Complete septate uterus with longitudinal vaginal septum

Genome-based expression profiling as a single standardized microarray platform for the diagnosis of endometrial disorder: an array of 126-gene model

Increased expression of c-fos protein associated with increased matrix metalloproteinase-9 protein expression in the endometrium of endometriotic patients

Different types of small nerve fibers in eutopic endometrium and myometrium in women with endometriosis Natsuko Tokushige, Ph.D., Robert Markham, Ph.D.,

Local injury to the endometrium in controlled ovarian hyperstimulation cycles improves implantation rates Liang Zhou, M.D., Rong Li, M.D., Ph.D., Rong.

Fernando Zegers-Hochschild, M.D. Fertility and Sterility

Randomized, controlled trial comparing the efficacy of intrauterine balloon and intrauterine contraceptive device in the prevention of adhesion reformation.

Thyroid antibodies and gestational diabetes mellitus: a meta-analysis

Michael M. Alper, M.D. Fertility and Sterility

Ya-Nan Chang, M. M. , Ying Zhang, M. D. , Yong-Jun Wang, M. D

Lymph node involvement and lymphovascular invasion in deep infiltrating rectosigmoid endometriosis Jean-Christophe Noël, M.D., Charles Chapron, M.D.,

Hypoxia inducible factor and microvessels in peri-implantation endometrium of women with recurrent miscarriage Xiaoyan Chen, M.Phil., Lingming Jiang,

Ovarian pregnancy after in vitro fertilization

Conservative management of cervical ectopic pregnancy

Xinmei Zhang, M. D. , Bangchun Lu, M. D. , Xiufeng Huang, M. D

Evaluation of the immature human oocytes from unstimulated cycles in polycystic ovary syndrome patients using a novel scoring system Shan Liu, M.D.,

Differential expression of vascular endothelial growth factor angiogenic factors in different endometrial compartments in women who have an elevated progesterone.

Medical treatment of ectopic pregnancy: a committee opinion

Human Mousavi Fatemi, M. D. , Ph. D. , Biljana Popovic-Todorovic, M. D

Yang Li, Ph.D., Ji-chun Tan, M.D., Ph.D., Ling-song Li, M.D., Ph.D.

Dendritic cells are equally distributed in intrauterine and tubal ectopic pregnancies Birgit Kemp, Ph.D., Svenja Schmitz, M.D., Claudia A. Krusche, Ph.D.,

Expression of angiopoietins 1, 2 and their common receptor tie-2 in relation to the size of endothelial lining gaps and expression of VEGF and VEGF receptors.

Increased matrix metalloproteinase-2 and tissue inhibitor of metalloproteinase-1 secretion but unaffected invasiveness of endometrial stromal cells in.

Oocyte cryopreservation

Genome-based expression profiling as a single standardized microarray platform for the diagnosis of endometrial disorder: an array of 126-gene model

Immunohistochemical detection of aquaporin expression in eutopic and ectopic endometria from women with endometriomas Xiu-Xiu Jiang, M.D., Riu-Jin Wu,

Submucosal uterine leiomyomas have a global effect on molecular determinants of endometrial receptivity Beth W. Rackow, M.D., Hugh S. Taylor, M.D. Fertility.

Nonclassic 21-hydroxylase deficiency presenting as endometrial hyperplasia with uterine bleeding in a 67-year-old woman Marguerite B. Vigliani, M.D.,

Dana B. McQueen, M. D. , M. A. S. , Candice O. Perfetto, M. D

Xiao-Yu Pan, Ph. D. , Xue Li, M. D. , Zhan-Ping Weng, Ph. D

Effect of mifepristone on the expression of endometrial secretory leukocyte protease inhibitor in new medroxyprogesterone acetate users Aimin Li, M.D.,

Uterine adenomyoma presenting as a vesico-uterine endometrioma

Uterine rudiments in patients with Mayer-Rokitansky-Küster-Hauser syndrome consist of typical uterine tissue types with predominantly basalis-like endometrium

Kaylon L. Bruner-Tran, Ph. D. , Alessandra C. Carvalho-Macedo, M. D

HOXA-10 and E-cadherin expression in the endometrium of women with recurrent implantation failure and recurrent miscarriage Yihua Yang, Ph.D., Xiaoyan.

Xiuye Xing, M. D. , Ph. D. , Han Zhao, M. D. , Ph. D. , Mei Li, M. Sc

Application of three-dimensional fluorescence in situ hybridization to human preimplantation genetic diagnosis Li-Ying Yan, Ph.D., Jie Qiao, M.D., Yuan.

Thickened endometrial stripe in women with post-menopausal bleeding: an association with a common congenital uterine anomaly M.H. Amols, S.A. El-Nashar,

Clomiphene citrate at 50: the dawning of assisted reproduction

Aromatase inhibitor regulates let-7 expression and let-7f–induced cell migration in endometrial cells from women with endometriosis SiHyun Cho, M.D.,

Modulation of HOXA10 and other markers of endometrial receptivity by age and human chorionic gonadotropin in an endometrial explant model Robin H. Fogle,

Novel noninvasive detection method for endometriosis: research and development of scintigraphic survey on endometrial implants in rats Seyma Hascalik,

Letrozole stimulates the growth of human endometrial explants cultured in three- dimensional fibrin matrix Mozafar Khazaei, Ph.D., Azadeh Montaseri, M.Sc.,

Mara Curaba, M. Sc. , Jonathan Poels, M. Sc

Interstitial pregnancy

CDB-2914, a novel selective progesterone receptor modulator, differentially regulates endometrial gene expression in the proliferative phase of the menstrual.

Immunofluorescence Localization Of Epithelial Cadherin, Cross Reactive With An Antibody Against Human Placental Protein, In Human Preimplantation Embryos

GnRH antagonists may affect endometrial receptivity

Multiple extrauterine adenomyomas and uterus-like masses: case reports and review of the literature Silvestro Carinelli, M.D., Francesca Motta, M.D.,

P-425 Fertility and Sterility Volume 86, Issue 3, (September 2006)

A case of giant cystic adenomyosis

Effect of the immunomodulator leflunomide on the induction of endometriosis in an experimental rat model Hakan Aytan, M.D., Pinar Caglar, M.D., Dilek.

Microvascular density, vascular endothelial growth factor A, and its receptors in endometrial blood vessels in patients with menorrhagia Miriam Mints,

L. Scott, J. Bernsten, K. DeLegge, J. Hill, N. Ramsing

Fertility and Sterility: an evaluation

Effect of ovarian steroids on gene expression profile in human uterine microvascular endothelial cells Tadahiro Yasuo, M.D., Kotaro Kitaya, M.D. Fertility.

Differences in gene expression in the proliferative human endometrium

Absence of endometrium as a cause of primary amenorrhea

Current evaluation of amenorrhea

A study of luteal phase expression of inhibin, activin, and follistatin subunits in the endometrium of women with recurrent miscarriage Alka Prakash,

Fast action of estrogen on intracellular calcium in dormant mouse blastocyst and its possible mechanism Lin-lin Yu, M.Sc., Jin-hu Zhang, M.B., Ya-ping.

Nerve fibers and menstrual cycle in peritoneal endometriosis

In vitro sildenafil citrate use as a sperm motility stimulant

Haggar Harduf, M.Sc., Shlomit Goldman, D.Sc., Eliezer Shalev, M.D.

Daniel R. Grow, M.D., Khosro Iromloo, M.D. Fertility and Sterility

Moamar Al-Jefout, M. D. , Kirsten Black, M. D. , Lauren Schulke, M. Sc

Endometrial polyps affect uterine receptivity

Lauren F. Damle, M. D. , Veronica Gomez-Lobo, M. D. , Amy R. Andrus, M

Presentation transcript:

Low-dose mifepristone increases uterine natural killer cell cytotoxicity and perforin expression during the receptive phase Feng Zhou, M.M., Xiu-Ying Chen, M.M., Ya-Ling Zhuang, M.D., Yue-Zhou Chen, M.D., Li-Li Huang, M.D. Fertility and Sterility Volume 96, Issue 3, Pages 649-653 (September 2011) DOI: 10.1016/j.fertnstert.2011.06.074 Copyright © 2011 American Society for Reproductive Medicine Terms and Conditions

Figure 1 Morphological characteristics of endometrium before and after culture with mifepristone. Sections of endometrial explants were stained with hematoxylin and eosin (H & E) before culture (A), or after 24 hours in culture with 0 (B), 65 (C), and 200 nmol/L mifepristone (D). Magnification, ×200. Fertility and Sterility 2011 96, 649-653DOI: (10.1016/j.fertnstert.2011.06.074) Copyright © 2011 American Society for Reproductive Medicine Terms and Conditions

Figure 2 Comparative analysis of the effects of mifepristone on expression of perforin by uterine natural killer cells during the receptive phase. Perforin (black) expression was localized in the cytoplasm and CD56 (red) expression was localized on the cell membrane of endometrial explants after 24 hours in culture with 0 (A), 65 (B), and 200 nmol/L mifepristone (C). Cells double-labeled with antibodies against perforin and CD56 are indicated with white arrows. Magnification, ×400. Fertility and Sterility 2011 96, 649-653DOI: (10.1016/j.fertnstert.2011.06.074) Copyright © 2011 American Society for Reproductive Medicine Terms and Conditions