Combination of uterine natural killer cell immunoglobulin receptor haplotype and trophoblastic HLA-C ligand influences the risk of pregnancy loss: a retrospective.

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Presentation transcript:

Combination of uterine natural killer cell immunoglobulin receptor haplotype and trophoblastic HLA-C ligand influences the risk of pregnancy loss: a retrospective cohort analysis of direct embryo genotyping data from euploid transfers Scott J. Morin, M.D., Nathan R. Treff, Ph.D., Xin Tao, M.S., Richard T. Scott, B.S., Jason M. Franasiak, M.D., Caroline R. Juneau, M.D., Marcy Maguire, M.D., Richard T. Scott, M.D., H.C.L.D. Fertility and Sterility Volume 107, Issue 3, Pages 677-683.e2 (March 2017) DOI: 10.1016/j.fertnstert.2016.12.004 Copyright © 2016 American Society for Reproductive Medicine Terms and Conditions

Figure 1 Uterine natural killer cell immunoglobulin receptor (KIR) haplotype determination. Each patient carries multiple KIR genotypes. If all genotypes in a given patient are inhibiting, she is a carrier of the KIR A haplotype. If she carries a combination of inhibitory and activating genotypes, she is a carrier of the KIR B haplotype. Fertility and Sterility 2017 107, 677-683.e2DOI: (10.1016/j.fertnstert.2016.12.004) Copyright © 2016 American Society for Reproductive Medicine Terms and Conditions

Figure 2 Possible combinations of trophoblastic HLA-C ligands and maternal uterine natural killer cell immunoglobulin receptors (KIRs). There are six possible HLA-KIR combinations at the fetomaternal interface, based on trophoblastic HLA zygosity and maternal KIR haplotype. Fertility and Sterility 2017 107, 677-683.e2DOI: (10.1016/j.fertnstert.2016.12.004) Copyright © 2016 American Society for Reproductive Medicine Terms and Conditions

Figure 3 Pregnancy loss according to HLA-KIR combination. Among KIR A haplotype carriers, the risk of pregnancy loss was significantly higher if the embryo transferred was C2/C2 (P<.01). Among C1/C1 embryos, the chance or pregnancy loss was significantly higher if the recipient was a KIR B haplotype carrier (P<.01). KIR = uterine natural killer cell immunoglobulin receptor. Fertility and Sterility 2017 107, 677-683.e2DOI: (10.1016/j.fertnstert.2016.12.004) Copyright © 2016 American Society for Reproductive Medicine Terms and Conditions