Association Between Proton Pump Inhibitor Therapy and Clostridium difficile Infection in a Meta-Analysis Abhishek Deshpande, Chaitanya Pant, Vinay Pasupuleti,

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Presentation transcript:

Association Between Proton Pump Inhibitor Therapy and Clostridium difficile Infection in a Meta-Analysis Abhishek Deshpande, Chaitanya Pant, Vinay Pasupuleti, David D.K. Rolston, Anil Jain, Narayan Deshpande, Priyaleela Thota, Thomas J. Sferra, Adrian V. Hernandez Clinical Gastroenterology and Hepatology Volume 10, Issue 3, Pages 225-233 (March 2012) DOI: 10.1016/j.cgh.2011.09.030 Copyright © 2012 AGA Institute Terms and Conditions

Figure 1 Study selection process. Clinical Gastroenterology and Hepatology 2012 10, 225-233DOI: (10.1016/j.cgh.2011.09.030) Copyright © 2012 AGA Institute Terms and Conditions

Figure 2 Funnel plot to assess publication bias. Clinical Gastroenterology and Hepatology 2012 10, 225-233DOI: (10.1016/j.cgh.2011.09.030) Copyright © 2012 AGA Institute Terms and Conditions

Figure 3 Overall analysis stratified by study design (all studies). Clinical Gastroenterology and Hepatology 2012 10, 225-233DOI: (10.1016/j.cgh.2011.09.030) Copyright © 2012 AGA Institute Terms and Conditions

Figure 4 (A) Subgroup analysis of case-control studies by percentage of antibiotic use as defined in all the population (CDI + no CDI). (B) Subgroup analysis of case-control studies by percentage of antibiotic use with studies with no information for antibiotic use excluded. (C) Subgroup analysis of case-control studies by percentage of antibiotic use as defined in the CDI group (ie, cases only). (D) Subgroup analysis excluding 4 studies that evaluated recurrent CDI. Clinical Gastroenterology and Hepatology 2012 10, 225-233DOI: (10.1016/j.cgh.2011.09.030) Copyright © 2012 AGA Institute Terms and Conditions