Tranexamic acid administration for anatomic and reverse total shoulder arthroplasty: a systematic review and meta-analysis Hayden N. Box, MD, Breann.

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Tranexamic acid administration for anatomic and reverse total shoulder arthroplasty: a systematic review and meta-analysis Hayden N. Box, MD, Breann S. Tisano, BS, Michael Khazzam, MD JSES Open Access Volume 2, Issue 1, Pages 28-33 (March 2018) DOI: 10.1016/j.jses.2017.12.004 Copyright © 2018 The Author(s) Terms and Conditions

Figure 1 Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) flow diagram. JSES Open Access 2018 2, 28-33DOI: (10.1016/j.jses.2017.12.004) Copyright © 2018 The Author(s) Terms and Conditions

Figure 2 Forest plots of change in hemoglobin for combined (above) and reverse total shoulder arthroplasty (below). The squares indicate the mean difference and are proportional to the weights used in the meta-analysis. The horizontal lines represent the 95% confidence interval (CI). The diamond indicates the weighted mean difference, and the lateral tips of the diamond indicate the associated 95% CIs. The vertical line indicates no effect. TXA, tranexamic acid; SD, standard deviation; IV, inverse variance. JSES Open Access 2018 2, 28-33DOI: (10.1016/j.jses.2017.12.004) Copyright © 2018 The Author(s) Terms and Conditions

Figure 3 Forest plots of drain output for combined (top), reverse total shoulder arthroplasty (middle), and anatomic total shoulder arthroplasty (bottom). The squares indicate the mean difference and are proportional to the weights used in the meta-analysis. The horizontal lines represent the 95% confidence interval (CI). The diamond indicates the weighted mean difference, and the lateral tips of the diamond indicate the associated 95% CIs. The vertical line indicates no effect. TXA, tranexamic acid; SD, standard deviation; IV, inverse variance. JSES Open Access 2018 2, 28-33DOI: (10.1016/j.jses.2017.12.004) Copyright © 2018 The Author(s) Terms and Conditions

Figure 4 Forest plots of total blood loss for combined (above) and reverse total shoulder arthroplasty (below). The squares indicate the mean difference and are proportional to the weights used in the meta-analysis. The horizontal lines represent the 95% confidence interval (CI). The diamond indicates the weighted mean difference, and the lateral tips of the diamond indicate the associated 95% CIs. The vertical line indicates no effect. TXA, tranexamic acid; SD, standard deviation; IV, inverse variance. JSES Open Access 2018 2, 28-33DOI: (10.1016/j.jses.2017.12.004) Copyright © 2018 The Author(s) Terms and Conditions

Figure 5 Forest plots of risk of transfusion for combined (top), reverse total shoulder arthroplasty (middle), and anatomic total shoulder arthroplasty (bottom). The squares indicate the mean difference and are proportional to the weights used in the meta-analysis. The horizontal lines represent the 95% confidence interval (CI). The diamond indicates the weighted mean difference, and the lateral tips of the diamond indicate the associated 95% CIs. The vertical line indicates no effect. TXA, tranexamic acid; SD, standard deviation; IV, inverse variance. JSES Open Access 2018 2, 28-33DOI: (10.1016/j.jses.2017.12.004) Copyright © 2018 The Author(s) Terms and Conditions