Covering the Cover Gastroenterology Anson W. Lowe, Richard H. Moseley  Gastroenterology  Volume 150, Issue 3, Pages 539-542 (March 2016) DOI: 10.1053/j.gastro.2016.01.019 Copyright © 2016 AGA Institute Terms and Conditions

Figure 1 Receiver operator curves that reflect the overall all accuracy of symptom-based scores when different criteria are used for remission. (F) represents when both endoscopic and histologic criteria are combined to define remission. AUC, area under the curve. Gastroenterology 2016 150, 539-542DOI: (10.1053/j.gastro.2016.01.019) Copyright © 2016 AGA Institute Terms and Conditions

Figure 2 Relationship between liver stiffness measurement (LSM) obtained using MRE or TE and liver fibrosis stage in control subjects and patients with NAFLD. (A) A steady stepwise increase in LSM for both MRE and TE was observed with increasing severity of liver fibrosis (Kruskal-Wallis test; P < .001). (B) The diagnostic accuracy of the LSM obtained using MRE or TE for liver fibrosis stage in patients with NAFLD. The AUROC curve is shown regarding the performance of the LSM in distinguishing liver fibrosis stage 0 from stages 1−4, 0−1 from 2−4, 0–2 from 3−4, and 0−3 from 4. Gastroenterology 2016 150, 539-542DOI: (10.1053/j.gastro.2016.01.019) Copyright © 2016 AGA Institute Terms and Conditions

Figure 3 Fsk-stimulated fluid secretion by cystic fibrosis transmembrane conductance regulator (CFTR) as measured by changes in the enteroid cross-sectional area. Fsk, forskolin, which increases cyclic adenosine monophosphate; EIPA, 5-(N-ethyl-N-isopropyl)amiloride, a general NHE inhibitor; S3226, specific NHE3 inhibitor; CFTRinh-172, a selective CFTR channel blocker; bumetanide, inhibitor of NKCC1-mediated cation-chloride uptake into the cell. Gastroenterology 2016 150, 539-542DOI: (10.1053/j.gastro.2016.01.019) Copyright © 2016 AGA Institute Terms and Conditions

Figure 4 Intracellular location of missfolded BMP6 mutants. (A) BMP6 protein expression in the liver biopsy specimens of patient 4 (lower panel) and a healthy control (upper panel). Arrows indicate apparent cytosolic aggregates of mutated BMP6 protein. (B) Subcellular location of BMP6 WT and mutants in OK cells transfected with the corresponding plasmid expressing the DDK-tagged fusion protein. These cells subsequently were fixed and DDK–BMP6 proteins were immunostained with anti-DDK antibody (green). The actin and nucleus were stained with Alexa Fluor 635 phalloidin (red) and Hoechst dye (blue), respectively. The images show the abnormal accumulation of the p.Leu96Pro mutant protein in intracellular compartments. Scale bars: 100 μm and 30 μm for biopsy specimens and confocal images, respectively. Gastroenterology 2016 150, 539-542DOI: (10.1053/j.gastro.2016.01.019) Copyright © 2016 AGA Institute Terms and Conditions