Andrew W. Siefert, MS, Jorge H. Jimenez, PhD, Kevin J

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Presentation transcript:

Contractile mitral annular forces are reduced with ischemic mitral regurgitation Andrew W. Siefert, MS, Jorge H. Jimenez, PhD, Kevin J. Koomalsingh, MD, Fernando Aguel, MS, Dustin S. West, BS, Takashi Shuto, MD, Teresa K. Snow, PhD, Robert C. Gorman, MD, Joseph H. Gorman, MD, Ajit P. Yoganathan, PhD The Journal of Thoracic and Cardiovascular Surgery Volume 146, Issue 2, Pages 422-428 (August 2013) DOI: 10.1016/j.jtcvs.2012.10.006 Copyright © 2013 The American Association for Thoracic Surgery Terms and Conditions

Figure 1 Developed mitral annular force transducer with measurement directions and features identified. (A) One-millimeter-diameter suture passages placed in 4-mm increments from the centerline of each measurement arm for transducer–annulus anchoring. (B) Strain gauge to measure septal–lateral force. (C) Strain gauge to measure transverse force. (D) Transducer spring element. (E) Exit wire harness. (F) Posterior mitral leaflet. (G) Anterior mitral leaflet. (H) Mitral annulus. The Journal of Thoracic and Cardiovascular Surgery 2013 146, 422-428DOI: (10.1016/j.jtcvs.2012.10.006) Copyright © 2013 The American Association for Thoracic Surgery Terms and Conditions

Figure 2 Representative unfiltered forces from both a control animal (A) and chronic IMR animal (B) are plotted with time and left ventricular pressure. IMR, Ischemic mitral regurgitation. The Journal of Thoracic and Cardiovascular Surgery 2013 146, 422-428DOI: (10.1016/j.jtcvs.2012.10.006) Copyright © 2013 The American Association for Thoracic Surgery Terms and Conditions

Figure 3 (A) The measured change in septal–lateral force throughout the cardiac cycle was observed to to be significantly greater in the control animals at each level of peak left ventricular pressure. (B) No significant differences in the change in transverse force throughout the cardiac cycle was observed between the animal groups and left ventricular pressure levels. IMR, Ischemic mitral regurgitation. *P < .01. †P < .005. The Journal of Thoracic and Cardiovascular Surgery 2013 146, 422-428DOI: (10.1016/j.jtcvs.2012.10.006) Copyright © 2013 The American Association for Thoracic Surgery Terms and Conditions