Follicular fluid and serum levels of Inhibin A and pregnancy-associated plasma protein A in patients undergoing IVF Jiri Moos, Ph.D., Vanda Filova, Ph.D.,

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Follicular fluid and serum levels of Inhibin A and pregnancy-associated plasma protein A in patients undergoing IVF Jiri Moos, Ph.D., Vanda Filova, Ph.D., Jana Pavelkova, M.D., Martina Moosova, M.Sc., Jana Peknicova, Ph.D., Karel Rezabek, M.D., Ph.D. Fertility and Sterility Volume 91, Issue 5, Pages 1739-1744 (May 2009) DOI: 10.1016/j.fertnstert.2008.01.102 Copyright © 2009 American Society for Reproductive Medicine Terms and Conditions

Figure 1 Follicular fluid/serum barrier permeability is dependent on serum protein molecular mass. Concentrations of major serum proteins (immunoglobulin M, Immunoglobulin A, immunoglobulin G,Transferrin, serum albumin, Apoprotein A, α1-antitrypsim and α1-acid-glycoprotein) were measured in 32 paired serum and FF samples. The FF/serum ratio in individual paired samples was plotted against the molecular mass of proteins on a logarithmic scale. Data were analyzed using linear regression analysis. Both FF and serum samples were collected on the day of oocyte retrieval. Only FF from large dominant follicles was collected and analyzed. Fertility and Sterility 2009 91, 1739-1744DOI: (10.1016/j.fertnstert.2008.01.102) Copyright © 2009 American Society for Reproductive Medicine Terms and Conditions

Figure 2 Correlation between concentrations of proteins in paired samples of follicular fluid and serum. Results of Inhibin A, PAPP-A and α1-acid glycoprotein are shown. Data were analyzed using linear regression analysis. The FF and serum samples were collected at the day of oocyte retrieval. Only FF from large dominant follicles was collected and analyzed. Fertility and Sterility 2009 91, 1739-1744DOI: (10.1016/j.fertnstert.2008.01.102) Copyright © 2009 American Society for Reproductive Medicine Terms and Conditions

Figure 3 Correlation between the total amount of ovarian proteins in FF and their serum concentration in paired samples. Results of Inhibin A and PAPP-A measurement are shown. Data were analyzed using linear regression analysis. The FF and serum samples were collected on the day of oocyte retrieval. The FF from all follicles was collected, pooled, and analyzed in this experiment. Fertility and Sterility 2009 91, 1739-1744DOI: (10.1016/j.fertnstert.2008.01.102) Copyright © 2009 American Society for Reproductive Medicine Terms and Conditions