Cognitive functioning and depressive symptoms in PCOS: associations with hormone levels and metabolic factors. Arkadiusz Dudek, Agnieszka Witkowska Tutors: dr n. med. Krzysztof Krysta, dr n. med. Grzegorz Franik Students’ Scientific Society, Department of Rehabilitation Psychiatry Students’ Scientific Society, Department of Endocrinological Gynecology Medical University of Silesia in Katowice

Introduction Polycystic ovary syndrome (PCOS) affects 6.6–8 % of women in reproductive age PCOS is connected with abnormalities in hormones levels, especially androgens Insulin resistance

What is known already In patients with PCOS depressive and anxiety symptoms are more common Differences in cognitive performance was reported in patients with PCOS verbal fluency verbal memory manual dexterity visuospatial working memory Tu jeszcze powiedzieć o związku z testosteronem

Aim of the study Analyse if there are assosiations between: Cognitive deficits Depressive symptoms Metabolic risk factors Hormone levels

Methods 55 women (mean age 24.35 ± 4.2) diagnosed with PCOS Diagnosis based on Rotterdam criteria All participants underwent a battery of neuropsychological and laboratory tests

Neuropsychological tests TMT A - psychomotor speed, attention and spatial organization TMT B - attention switching, mental flexibility and recall

Verbal Fluency Tests - attention, memory, verbal fluency and executive functions Beck Depression Inventory The Stroop Test - selective attention, cognitive flexibility and processing speed

Laboratory tests Hormones: estradiol, FSH, LH, total & free testosterone, 17-OH-progesterone, androstenedione, cortisol, DHEAS, SHBG, PRL, insulin Metabolic risk factors: glucose, total cholesterol, LDL, HDL, triglycerides, HOMA-IR, QUICKI Other: BMI, Waist Hip Ratio (WHR)

Beck Depression Inventory Results Beck Depression Inventory Fasting glucose -0,007 OGTT at120’ 0,330* Insulin at 120’ 0,21 Triglicerides 0,413** HDL - 0,357** Waist Hip Ratio 0,048 (*) significant at the level of p <0.05, (**) significant at the level of p <0.01

Black Stroop Colour Phonological fluency Fasting glucose 0,067 0,315* 0,067 0,315* OGTT at120’ 0,306* 0,047 -0,244 Insulin at 120’ 0,283* 0,225 -0,13 Triglicerides 0,058 0,097 -0,081 HDL 0,095 -0,04 -0,066 Waist Hip Ratio 0,252 0,293* -0,121 (*) significant at the level of p <0.05, (**) significant at the level of p <0.01

Beck DI Black Stroop Colour Stroop Phonological fluency SHBG -0,325* -0,03 -0,051 -0,085  Androstenedion 0,01 0,139 0,305* -0,093  17-OH-progesterone -0,065 0,034 -0,088 -0,310* Cortisol at 10 pm -0,105 0,283* -0,029 -0,281* Free testosteron -0,237 -0,276* 0,086 0,042 (*) significant at the level of p <0.05

Conclusions Metabolic factors are connected with depressive symptoms Different androgens are correlated with different cognitive functions Insulin resistance parameters are associated with worse verbal psychomotor speed Study supports the view that

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