Richard G. Carroll, Seamus J. Martin Cancer Cell

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Autophagy in Multiple Myeloma: What Makes You Stronger Can Also Kill You Richard G. Carroll, Seamus J. Martin Cancer Cell Volume 23, Issue 4, Pages 425-426 (April 2013) DOI: 10.1016/j.ccr.2013.04.001 Copyright © 2013 Elsevier Inc. Terms and Conditions

Figure 1 Caspase-10 Puts a Brake on Autophagy in Multiple Myeloma (A) Under steady-state conditions in multiple myeloma, a FLIPL/caspase-10 complex cleaves and inactivates BCLAF1 preventing its participation in autophagy. (B) Upon inhibition or knockdown of caspase-10, BCLAF1 becomes stabilized, displacing Bcl-2 from Beclin-1, leading to excessive autophagy followed by autophagic cell death. Cancer Cell 2013 23, 425-426DOI: (10.1016/j.ccr.2013.04.001) Copyright © 2013 Elsevier Inc. Terms and Conditions