Reprogramming Enhancers to Drive Metastasis

Slides:

Advertisements

Similar presentations

Aurora Kinases and Protein Phosphatase 1 Mediate Chromosome Congression through Regulation of CENP-E Yumi Kim, Andrew J. Holland, Weijie Lan, Don W. Cleveland.

Advertisements

SOD1 Integrates Signals from Oxygen and Glucose to Repress Respiration Amit R. Reddi, Valeria C. Culotta Cell Volume 152, Issue 1, Pages (January.

Individualized Medicine from Prewomb to Tomb Eric J. Topol Cell Volume 157, Issue 1, Pages (March 2014) DOI: /j.cell Copyright.

The RAG Recombinase Dictates Functional Heterogeneity and Cellular Fitness in Natural Killer Cells Jenny M. Karo, David G. Schatz, Joseph C. Sun Cell Volume.

What We Talk About When We Talk About Fat Evan D. Rosen, Bruce M. Spiegelman Cell Volume 156, Issue 1, Pages (January 2014) DOI: /j.cell

Molecular and Genetic Properties of Tumors Associated with Local Immune Cytolytic Activity Michael S. Rooney, Sachet A. Shukla, Catherine J. Wu, Gad Getz,

Origins of Metastatic Traits Sakari Vanharanta, Joan Massagué Cancer Cell Volume 24, Issue 4, Pages (October 2013) DOI: /j.ccr

Making Proteins in the Powerhouse B. Martin Hällberg, Nils-Göran Larsson Cell Metabolism Volume 20, Issue 2, Pages (August 2014) DOI: /j.cmet

Common Sense about Taste: From Mammals to Insects David A. Yarmolinsky, Charles S. Zuker, Nicholas J.P. Ryba Cell Volume 139, Issue 2, Pages (October.

Eph-Ephrin Bidirectional Signaling in Physiology and Disease Elena B. Pasquale Cell Volume 133, Issue 1, Pages (April 2008) DOI: /j.cell

Xenobiotics Shape the Physiology and Gene Expression of the Active Human Gut Microbiome Corinne Ferrier Maurice, Henry Joseph Haiser, Peter James Turnbaugh.

Cancer Metabolism Cell Volume 148, Issue 3, (February 2012) DOI: /j.cell Copyright © 2012 Terms and Conditions Terms and Conditions.

Computational Modeling of Pancreatic Cancer Reveals Kinetics of Metastasis Suggesting Optimum Treatment Strategies Hiroshi Haeno, Mithat Gonen, Meghan.

Evolution of the Cancer Stem Cell Model Antonija Kreso, John E. Dick Cell Stem Cell Volume 14, Issue 3, Pages (March 2014) DOI: /j.stem

Nuclear Receptors, RXR, and the Big Bang Ronald M. Evans, David J. Mangelsdorf Cell Volume 157, Issue 1, Pages (March 2014) DOI: /j.cell

The Landscape of Microsatellite Instability in Colorectal and Endometrial Cancer Genomes Tae-Min Kim, Peter W. Laird, Peter J. Park Cell Volume 155, Issue.

Module Map of Stem Cell Genes Guides Creation of Epithelial Cancer Stem Cells David J. Wong, Helen Liu, Todd W. Ridky, David Cassarino, Eran Segal, Howard.

The Good Fat Cell Volume 147, Issue 7, (December 2011) DOI: /j.cell Copyright © 2011 Terms and Conditions Terms and Conditions.

Pulsed Forces Timed by a Ratchet-like Mechanism Drive Directed Tissue Movement during Dorsal Closure Jerome Solon, Aynur Kaya-Çopur, Julien Colombelli,

Shaping Genetic Alterations in Human Cancer: The p53 Mutation Paradigm Thierry Soussi, Klas G. Wiman Cancer Cell Volume 12, Issue 4, Pages (October.

Gastrulation Movements: the Logic and the Nuts and Bolts Maria Leptin Developmental Cell Volume 8, Issue 3, Pages (March 2005) DOI: /j.devcel

Tumor Dissemination: An EMT Affair

Volume 14, Issue 6, Pages (June 2014)

A Pro-metastatic tRNA Pathway

Linking miRNA Regulation to BCR-ABL Expression: The Next Dimension

Tissue Culture as a Hostile Environment: Identifying Conditions for Breast Cancer Progression Studies Jerry W. Shay, Woodring E. Wright Cancer Cell

Metastasis gets site specific

Jens T. Siveke, Roland M. Schmid Cancer Cell

The Lingering Enigma of the Allelic Exclusion Mechanism

Driving Glioblastoma to Drink

Genetic Modifiers of the Breast Tumor Microenvironment

RAS unplugged: Negative feedback and oncogene-induced senescence

When Deletions Gain Functions: Commandeering Epigenetic Mechanisms

Cross-Species Oncogenomics in Cancer Gene Identification

Insights into the Neural and Genetic Basis of Vocal Communication

Volume 154, Issue 1, Pages (July 2013)

Tissue Culture as a Hostile Environment: Identifying Conditions for Breast Cancer Progression Studies Jerry W. Shay, Woodring E. Wright Cancer Cell

New Views into the Genetic Landscape of Metastatic Breast Cancer

In This Issue Cell Volume 158, Issue 5, (August 2014)

Opening a Chromatin Gate to Metastasis

Volume 4, Issue 1, Pages 4-6 (July 2003)

MicroRNAs and Parallel Stem Cell Lives

Heike Döppler, Peter Storz Cell Metabolism

It’s a SMAD/SMAD World Cell

KLF4 Initiates Acinar Cell Reprogramming and Is Essential for the Early Stages of Pancreatic Carcinogenesis Ravikanth Maddipati, Jonathan P. Katz Cancer.

Rushika M. Perera, Nabeel Bardeesy Cancer Cell

David A. Tuveson, John P. Neoptolemos Cell

Volume 152, Issue 1, (January 2013)

Tumor Self-Seeding: Bidirectional Flow of Tumor Cells

Soil Primes the Seed: Epigenetic Landscape Drives Tumor Behavior

Volume 130, Issue 6, (September 2007)

Yibin Kang, Klaus Pantel Cancer Cell

Gizem Donmez, Diana Wang, Dena E. Cohen, Leonard Guarente Cell

Stem Cells and Cancer: Two Faces of Eve

Easy Stress Relief by EZH2

Copyright © 2013 Elsevier Inc. All rights reserved.

Soil Primes the Seed: Epigenetic Landscape Drives Tumor Behavior

Volume 143, Issue 6, (December 2010)

The Cell Biology of Genomes: Bringing the Double Helix to Life

Volume 14, Issue 4, Pages (October 2008)

Learning from the Uncontrollable

Statistical Mechanics of Pluripotency

Volume 163, Issue 4, (November 2015)

Volume 163, Issue 2, (October 2015)

YAP1 Takes Over when Oncogenic K-Ras Slumbers

Volume 134, Issue 6, (September 2008)

Volume 19, Issue 4, Pages (April 2014)

Volume 12, Issue 6, Pages (December 2007)

In This Issue Cell Volume 145, Issue 3, (April 2011)

Volume 148, Issue 1, (January 2012)

Presentation transcript:

Reprogramming Enhancers to Drive Metastasis Raul Mostoslavsky, Nabeel Bardeesy Cell Volume 170, Issue 5, Pages 823-825 (August 2017) DOI: 10.1016/j.cell.2017.08.010 Copyright © 2017 Elsevier Inc. Terms and Conditions

Figure 1 Enhancer Reprogramming in Pancreatic Cancer Metastasis A schematic diagram depicting a series of events, as seen during pancreatic cancer progression. While specific genetics events have been described for normal pancreatic epithelial cells to give rise to primary pancreatic adenocarcinoma, here, the authors identified a FOXA1-dependent epigenetic reprogramming of enhancers as a major mechanism behind the progression of primary tumors to metastatic lesions. Such reprogramming activates genes related to foregut endoderm development, suggesting that these metastatic lesions undergo a retrograde developmental transition. Cell 2017 170, 823-825DOI: (10.1016/j.cell.2017.08.010) Copyright © 2017 Elsevier Inc. Terms and Conditions