Figure 4 Relationship of thickness of retinal layers to quality of life and low-contrast visual acuity Scatter plot and fitted linear regression line showing.

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Figure 4 Relationship of thickness of retinal layers to quality of life and low-contrast visual acuity Scatter plot and fitted linear regression line showing relationships of ganglion cell layer plus inner plexiform layer (GCL + IPL) thickness to 25-item National Eye Institute Visual Functioning Questionnaire (NEI-VFQ-25) composite scores and low-contrast visual acuity at 2.5% level. Relationship of thickness of retinal layers to quality of life and low-contrast visual acuity Scatter plot and fitted linear regression line showing relationships of ganglion cell layer plus inner plexiform layer (GCL + IPL) thickness to 25-item National Eye Institute Visual Functioning Questionnaire (NEI-VFQ-25) composite scores and low-contrast visual acuity at 2.5% level. The regression lines represent fitted values for mean GCL + IPL thickness for each value of NEI-VFQ-25 or low-contrast visual acuity; the gray shaded areas show the 95% confidence intervals from the SEs of the predictions for the fitted lines. Linear correlations were significant. QOL = quality of life. Reprinted from Ophthalmology 119(6), Walter SD et al., Ganglion cell loss in relation to visual disability in multiple sclerosis, 1250–1257, 2012, with permission from Elsevier.26 Steven L. Galetta et al. Neurol Neuroimmunol Neuroinflamm 2015;2:e135 © 2015 American Academy of Neurology