Capacity training and development Work Package 2 Capacity training and development Lead: Professor Sir Ali Zumla Sheraton Hotel, Schiphol Amsterdam Airport

Sheraton Hotel, Schiphol Amsterdam Airport JEEs Assessed out of 5: 1. No capacity is in place 2. Limited capacity. Attributes are in developmental phase 3. Developed capacity. Attributes are in place, sustainability has not been ensured 4. Demonstrated capacity. Attributes are in place and are sustainable for a few years 5. Sustainable capacity. All attributes are functional and sustainable and the country is supporting others in implementation Thanks to Linzy Elton for slide Sheraton Hotel, Schiphol Amsterdam Airport

Sheraton Hotel, Schiphol Amsterdam Airport PANDORA-ID-NET Division of Infection and Immunity PANDORA country overview Ghana Sudan Sierra Leone Uganda Nigeria Tanzania Gabon Republic of Congo Zambia Thanks to Linzy Elton for slide Sheraton Hotel, Schiphol Amsterdam Airport

JEE scores for PANDORA countries   Country Country Average Prevent Detect Respond Other Ghana 2.23 2.39 2.54 1.63 2.33 Nigeria 2.06 1.93 2.56 1.31 1.83 Sierra Leone 2.02 1.82 1.92 2.44 Tanzania 2.29 2.55 2.25 2.00 2.50 Uganda 2.70 2.51 3.21 2.19 1.67 Zambia 2.35 2.38 2.60 1.13 DRC 1.98 1.80 2.62 1.43 1.33 Africa Average 2.26 2.09 1.95 1.54 Thanks to Linzy Elton for analysis Sheraton Hotel, Schiphol Amsterdam Airport

Sheraton Hotel, Schiphol Amsterdam Airport Work Package 2 A training survey was sent out in December: We have 22 participant sites: 50% response rate Site & country FCRM, republic of Congo UCL, UK National institute for infectious diseases, Lazzaro, Spallanzani, Italy Chatham House, UK Njala University, Sierra Leone Royal Vet College, UK Sokoine University of Agriculture, Tanzania Uganda National Health Research, Uganda University of Khartoum, Sudan HerpeZ Ltd, Zambia Centre for Disease Control, Nigeria Site & country Charite – Germany Irru Specialist teaching hospital, Nigeria Bernhard-Nocht-Institut fur Tropenmedizin, Germany NIMR - Tanzania Institute of Tropical Medicine, Tübingen, Germany IHI Tanzania University of Ghana, Ghana KUNST, Ghana Emergency life support for civilian war victims, Italy Institut de Recherche pour development, France Centre for Recherches Medicales de Lambarene, Gabon Sheraton Hotel, Schiphol Amsterdam Airport

Training expertise by site SACIDS, Tanzania Infectious disease surveillance University of Ghana TB diagnostics, Genotyping Public engagement, communication, media-related expertise KUNST, Ghana Infectious disease diagnostics – multiple Scientific communication & research methods HerpeZ, Zambia TB, Surveillance studies, infectious disease diagnostics Irru Specialist teaching hospital, Nigeria Field operation of mobile lab during outbreak of highly infectious diseases Centre de Recherches Médicales de Lambaréné, Gabon Molecular diagnostics of dengue virus FRCM, Republic of Congo Training for ethics committee members, Training for regulatory authorities Malaria diagnostics University College London, UK TB diagnostics, Bacteriology & mycology diagnostics, Lab aspects of clinical trials Chatham House, UK Convening stakeholders, Media training, Infectious disease surveillance response, IHR, Country preparedness assessments Institute of Tropical Medicine, Tübingen, Germany Diagnostics – malaria, parasites, Hep B,D,E, sepsis causing pathogens + associated genes encoding for acquired extended ESBL or carbapenemases   Sheraton Hotel, Schiphol Amsterdam Airport

Training done in the last 2 years Site Training done in the last 2 years SACIDS, Tanzania Research ethics, Molecular diagnostic testing, disease surveillance University of Ghana LPA, Gene Xpert, influenza, HIV, Polio, water quality analysis Communication for development (C4D), Health communication, media reporting on specialised areas. KUNST, Ghana Molecular biology, Molecular genetics, Research methods, Scientific writing HerpeZ, Zambia Public health emergency management Emergency rapid response Irru Specialist teaching hospital, Nigeria PCR diagnostics for lassa fever & other VHFs Centre de Recherches Médicales de Lambaréné, Gabon Molecular diagnostics of dengue virus FRCM, Republic of Congo Ethics committee & regulatory authority members for evaluaton of research protocol in emergencies University College London, UK N/A Chatham House, UK Africa fellowship training Institute of Tropical Medicine, Tübingen, Germany   Sheraton Hotel, Schiphol Amsterdam Airport

Sheraton Hotel, Schiphol Amsterdam Airport Training planned for 2019-2020 Site Training done in the last 2 years SACIDS, Tanzania None reported University of Ghana Gene Xpert In planning KUNST, Ghana HerpeZ, Zambia Public health security & international health regulations Irru Specialist teaching hospital, Nigeria Mobile lab deployment in outbreak situations Centre de Recherches Médicales de Lambaréné, Gabon Immunology of infectious diseases FRCM, Republic of Congo Molecular diagnostics for Ebola, pathogen detection – ApoH, Research projects University College London, UK TB diagnostics workshop in collaboration with the NoEs – KCRI, Tanzania Chatham House, UK Africa fellowship training Institute of Tropical Medicine, Tübingen, Germany Seroprevalance & molecular diagnostics & r-eemerging pathogens   Sheraton Hotel, Schiphol Amsterdam Airport

Sheraton Hotel, Schiphol Amsterdam Airport WKP2 Deliverables Stakeholders meeting in London University College London (UCL) Stakeholders meeting in Gabon University of Tübingen Self reporting survey on preparedness status HerpeZ Limited Training Workshop 1 – hospital staff Training Workshop 2 – Researchers In collaboration with ALERRT MSc and PhDs in different discipline including social science Multi media training tools (videos and lessons plan Assessment of lab capacities National Institute for Infectious Diseases Lazzaro Spallanzani Plan for lab testing upgrade Bernhard-Nocht-Institut für Tropenmedizin Pathology diagnostics upgraded in all sites Establishment of 2 new mobile lab units in Africa Irrua Specialist Teaching Hospital Training of lab personnel in mobile lab operations including mock deployment Upgrade of existing mobile lab units in Africa Formation of advocacy and mobile lab network group Quality assurance and quality control Sheraton Hotel, Schiphol Amsterdam Airport

Sheraton Hotel, Schiphol Amsterdam Airport Work Package 2 SN Priority Problem Gaps Proposed intervention (through Pandora collaborating with National Public health institutions and other agencies) 1 Persisting Lassa fever outbreaks in Nigeria, Liberia, Togo, Benin republic, Sierra Leone -Weak surveillance (Few and ill-equipped labs) -inadequate trained staff - insufficient community engagement - Insufficient sub-regional coordination -Lab capacity strengthening mobile lab training and deployment Equip labs + staff Identify priority sub region with need for mobile lab capacity –Congo/Zimbabwe Training for frontline Health workers ( develop a standard training manual for Africa)   Lassa virus Rodent and Human seroprevalence studies in West Africa( pilot started) Training on community/social aspects of disease control 2 Recent Yellow fever outbreak especially in Nigeria Weak surveillance (Few and weak labs) Mass vaccination of high risk groups (ongoing by the NCDC) 3 Infection prevention and control -Assessment of IPC capacities especially Primary or low resource health care facilities (pilot started) 4 Health manpower development / Research capacity Research capacity low Train at least 2 Masters and 2 PhD candidates per country for above research projects ( 1 PhD student selected working on AMR in Nigeria) Table from Danny Asogun Sheraton Hotel, Schiphol Amsterdam Airport

Collaborative Projects Collaboration with Public Health England (PHE) Use a PCR-based assay for detection of multiple pathogens during outbreaks Use it as a workshop training tool Sheraton Hotel, Schiphol Amsterdam Airport

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