Characterization of Human Keratin-Associated Protein 1 Family Members

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Characterization of Human Keratin-Associated Protein 1 Family Members Yutaka Shimomura, Noriaki Aoki, Masaaki Ito Journal of Investigative Dermatology Symposium Proceedings Volume 8, Issue 1, Pages 96-99 (June 2003) DOI: 10.1046/j.1523-1747.2003.12180.x Copyright © 2003 The Society for Investigative Dermatology, Inc Terms and Conditions

Figure 1 Multi-alignment of hKAP1 family members. Residues that are identical are colored light blue. Dashes denote gaps in the sequence to maximize alignment. The pentapeptide repeats are boxed with black lines. Brackets show the five KAP subdomains. The unique nonrepetitive sequences in the repetitive I domain are boxed with red lines. The accession numbers for the respective protein sequences are: hKAP1.1A (hB2A), X63337; hKAP1.1B (AC007455, nt 8801–9334); hKAP1.2 (hB2B), X63338; hKAP1.3 (AC007455, nt 15377–15880); hKAP1.4 (AC007455, nt 20120–20485); hKAP1.5 (AC007455, nt 23043–23568); hKAP1.6 (AB052868); hKAP1.7 (AB055057). Journal of Investigative Dermatology Symposium Proceedings 2003 8, 96-99DOI: (10.1046/j.1523-1747.2003.12180.x) Copyright © 2003 The Society for Investigative Dermatology, Inc Terms and Conditions

Figure 2 Transcripts of hKAP1 genes are expressed in the cortex of the hair follicle. (A) hKAP1.1A/B, hKAP1.6, and hKAP1.7. (B) hKAP1.3. (C) hKAP1.5. Note that due to the high DNA sequence homology of the hKAP1.1A/B, hKAP1.6, and hKAP1.7 genes, the in situ probe used for (A) recognizes four transcripts. The red arrows demarcate the area of major KAP expression. No transcripts were detected in the medulla (data not shown) or in the ORS, IRS, and CU. ORS, outer root sheath; IRS, inner root sheath; CU, cuticle of the hair shaft; CO, cortex; DP, dermal papilla. Scale bar: 150 μm. Journal of Investigative Dermatology Symposium Proceedings 2003 8, 96-99DOI: (10.1046/j.1523-1747.2003.12180.x) Copyright © 2003 The Society for Investigative Dermatology, Inc Terms and Conditions