Preoperative statin treatment is associated with reduced postoperative mortality and morbidity in patients undergoing cardiac surgery: An 8-year retrospective.

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Presentation transcript:

Preoperative statin treatment is associated with reduced postoperative mortality and morbidity in patients undergoing cardiac surgery: An 8-year retrospective cohort study Leslie L. Clark, MS, John S. Ikonomidis, MD, PhD, Fred A. Crawford, MD, Arthur Crumbley, MD, John M. Kratz, MD, Martha R. Stroud, MS, Robert F. Woolson, PhD, James J. Bruce, MS, Joyce S. Nicholas, PhD, Daniel T. Lackland, DrPH, Michael R. Zile, MD, Francis G. Spinale, MD, PhD The Journal of Thoracic and Cardiovascular Surgery Volume 131, Issue 3, Pages 679-685 (March 2006) DOI: 10.1016/j.jtcvs.2005.11.006 Copyright © 2006 The American Association for Thoracic Surgery Terms and Conditions

Figure 1 Unadjusted percentages of 30-day morbidity and mortality for patients pretreated with statins (n = 1044) or not treated (n = 2785). *P < .05 versus not treated. The Journal of Thoracic and Cardiovascular Surgery 2006 131, 679-685DOI: (10.1016/j.jtcvs.2005.11.006) Copyright © 2006 The American Association for Thoracic Surgery Terms and Conditions

Figure 2 Comparison on odds ratios for unadjusted, adjusted, and propensity-matched models. The solid points represent the odds ratio, and the lines represent the 95% confidence interval. All of the odds ratios fall below the null value of 1, indicating a significantly reduced risk of 30-day mortality and morbidity outcome for patients pretreated with statins (P < .05 vs not treated). The Journal of Thoracic and Cardiovascular Surgery 2006 131, 679-685DOI: (10.1016/j.jtcvs.2005.11.006) Copyright © 2006 The American Association for Thoracic Surgery Terms and Conditions

Figure 3 Comparison of primary cause of mortality in patients pretreated with statins (number of events = 26) and not treated (number of events = 155). Primary cause of mortality was defined as the body system that was the first significant system that began to fail or was the precipitating system that ultimately led to the patient’s death. These systems were defined as follows: cardiac, myocardial infarction, arrhythmic disorder, cardiomyopathy, or heart failure; neurologic, stroke, cerebral bleed, embolism, or other neurologic event; pulmonary, respiratory insufficiency or failure, pneumonia, adult respiratory distress syndrome, ventilator dependence, or pulmonary edema; infection, any systemic or organ infection (ie, sepsis, sternal or wound, subacute bacterial endocarditis, or cellulitis); renal, renal failure, dialysis, or both; vascular, peripheral (arterial circulation) disorder, such as embolic event or circulatory dysfunction; other, cause other than those listed above, accidental, trauma, multiple organ failure, or other surgical intervention that led to patient’s death. The Journal of Thoracic and Cardiovascular Surgery 2006 131, 679-685DOI: (10.1016/j.jtcvs.2005.11.006) Copyright © 2006 The American Association for Thoracic Surgery Terms and Conditions