Adiponectin Concentrations: A Genome-wide Association Study

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Adiponectin Concentrations: A Genome-wide Association Study Sun Ha Jee, Jae Woong Sull, Jong-Eun Lee, Chol Shin, Jongkeun Park, Heejin Kimm, Eun-Young Cho, Eun-Soon Shin, Ji Eun Yun, Ji Wan Park, Sang Yeun Kim, Sun Ju Lee, Eun Jung Jee, Inkyung Baik, Linda Kao, Sungjoo Kim Yoon, Yangsoo Jang, Terri H. Beaty The American Journal of Human Genetics Volume 87, Issue 4, Pages 545-552 (October 2010) DOI: 10.1016/j.ajhg.2010.09.004 Copyright © 2010 The American Society of Human Genetics Terms and Conditions

Figure 1 Significance of SNPs in CDH13 for All Three Cohorts Discovery set, n = 979; replication set 1, n = 3,022; replication set 2, n = 2,034. Here, a linear regression model including age, gender, smoking status, and body mass index was used for each individual SNP. Top panel: plot showing the −log10(p value). Black, red, and white symbols represent data from the discovery study, replication set 1, and replication set 2, respectively. Bottom panel: plot showing the recombination rate (blue) and cumulative recombination rate measured away from the most highly associated SNP of rs3865188 (yellow). Positions of highly significant SNPs were upstream of CDH13. The American Journal of Human Genetics 2010 87, 545-552DOI: (10.1016/j.ajhg.2010.09.004) Copyright © 2010 The American Society of Human Genetics Terms and Conditions

Figure 2 –log10(p Value) for both Imputed and Genotyped SNPs in ADIPOQ in 4,001 Korean Adults Red dots are genotyped SNPs; open blue squares are imputed SNPs. The American Journal of Human Genetics 2010 87, 545-552DOI: (10.1016/j.ajhg.2010.09.004) Copyright © 2010 The American Society of Human Genetics Terms and Conditions