ADAb: anti-drug antibody.

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Presentation transcript:

ADAb: anti-drug antibody. Unless provided in the caption above, the following copyright applies to the content of this slide: © The Author(s) 2019. Published by Oxford University Press on behalf of the British Society for Rheumatology.This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0/), which permits non-commercial re-use, distribution, and reproduction in any medium, provided the original work is properly cited. For commercial re-use, please contact journals.permissions@oup.com Rheumatology (Oxford), kez030, https://doi.org/10.1093/rheumatology/kez030 The content of this slide may be subject to copyright: please see the slide notes for details.

ADAbs: anti-drug ... ADAbs: anti-drug antibodies; AEs: adverse events; NA: not available; TF: treatment failure; +: strong association with ADAbs; +/−: possible association with ADAbs; −: no association with ADAbs. Unless provided in the caption above, the following copyright applies to the content of this slide: © The Author(s) 2019. Published by Oxford University Press on behalf of the British Society for Rheumatology.This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0/), which permits non-commercial re-use, distribution, and reproduction in any medium, provided the original work is properly cited. For commercial re-use, please contact journals.permissions@oup.com Rheumatology (Oxford), kez030, https://doi.org/10.1093/rheumatology/kez030 The content of this slide may be subject to copyright: please see the slide notes for details.

Fig. 3 Random effects meta-analysis of concomitant MTX and the risk of ADAb development during adalimumab ... ADAbs: anti-drug antibodies; RR: risk ratio. Unless provided in the caption above, the following copyright applies to the content of this slide: © The Author(s) 2019. Published by Oxford University Press on behalf of the British Society for Rheumatology.This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0/), which permits non-commercial re-use, distribution, and reproduction in any medium, provided the original work is properly cited. For commercial re-use, please contact journals.permissions@oup.com Rheumatology (Oxford), kez030, https://doi.org/10.1093/rheumatology/kez030 The content of this slide may be subject to copyright: please see the slide notes for details.

Fig. 4 Course of action for treatment failure or hypersensitivity during JIA treatment with biologic ... Treatment failure (primary or secondary) or hypersensitivity-associated events: assess serum drug trough concentration. (i) Sufficient drug concentration: switch to a biologic agent of a different class. (ii) Insufficient drug concentration: measure ADAbs. (a) ADAb-negative: (1) assess and (re-)adjust dosage to patient’s weight; (2) assess and optimize therapeutic compliance; (3) optimal compliance and maximum dosage: switch to a biologic agent of a different class. (b) ADAb-positive: neutralize ADAbs: (1) immunosuppressive therapy, (2) dose escalation, (3) switch to another biologic agent – identical or different class. ADAb: anti-drug antibody; ?: research question for future research. Unless provided in the caption above, the following copyright applies to the content of this slide: © The Author(s) 2019. Published by Oxford University Press on behalf of the British Society for Rheumatology.This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0/), which permits non-commercial re-use, distribution, and reproduction in any medium, provided the original work is properly cited. For commercial re-use, please contact journals.permissions@oup.com Rheumatology (Oxford), kez030, https://doi.org/10.1093/rheumatology/kez030 The content of this slide may be subject to copyright: please see the slide notes for details.