A prospective trial of tacrolimus (FK 506) in clinical heart transplantation: Intermediate- term results Si M. Pham, MDa §, Robert L. Kormos, MDa, Brack.

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Presentation transcript:

A prospective trial of tacrolimus (FK 506) in clinical heart transplantation: Intermediate- term results Si M. Pham, MDa §, Robert L. Kormos, MDa, Brack G. Hattler, MDa §, Akihiko Kawai, MDa §, Athanassios C. Tsamandas, MDb §, Anthony J. Demetris, MDb §, Srinivas Murali, MDc §, Frederick J. Fricker, MDd §, Huang C. Chang, MDa §, Ashosk B. Jain, MDa §, Thomas E. Starzl, MD, PhDa §, Robert L. Hardesty, MDa, Bartley P. Griffith, MDa The Journal of Thoracic and Cardiovascular Surgery Volume 111, Issue 4, Pages 764-772 (April 1996) DOI: 10.1016/S0022-5223(96)70336-7 Copyright © 1996 Mosby, Inc. Terms and Conditions

Fig. 1 Actuarial survival of cardiac transplant recipients according to different immunosuppression protocols. The Journal of Thoracic and Cardiovascular Surgery 1996 111, 764-772DOI: (10.1016/S0022-5223(96)70336-7) Copyright © 1996 Mosby, Inc. Terms and Conditions

Fig. 2 Freedom from acute rejection (grade 3A or higher) according to different immunosuppression protocols. The actuarial freedom from rejection in patients who received triple-drug therapy without lympholytic induction (CyA alone) was lower (p < 0.01) than that of the FK 506 group. No difference in the freedom from rejection between the FK 506–treated patients and the CyA-treated patients who received lympholytic induction. The Journal of Thoracic and Cardiovascular Surgery 1996 111, 764-772DOI: (10.1016/S0022-5223(96)70336-7) Copyright © 1996 Mosby, Inc. Terms and Conditions

Fig. 3 Actuarial freedom from allograft coronary artery disease (CAD) in patients who received FK 506 versus those who received CyA-based regimen (with and without lympholytic induction). No difference was observed between the two groups (p = 0.07). The Journal of Thoracic and Cardiovascular Surgery 1996 111, 764-772DOI: (10.1016/S0022-5223(96)70336-7) Copyright © 1996 Mosby, Inc. Terms and Conditions

Fig. 4 Serum creatinine levels at various time points after transplantation in adult cardiac recipients receiving FK 506 and CyA. One year after transplantation, the serum creatinine levels were significantly higher than the pretransplant (PreTx) values for both groups (p < 0.01). There were no statistically significant difference in the serum creatinine concentrations between FK 506 and CyA groups. The Journal of Thoracic and Cardiovascular Surgery 1996 111, 764-772DOI: (10.1016/S0022-5223(96)70336-7) Copyright © 1996 Mosby, Inc. Terms and Conditions