Stop that Noise and Turn Up the Antisense Transcription

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Stop that Noise and Turn Up the Antisense Transcription Jan Steensels, Kevin J. Verstrepen Cell Reports Volume 15, Issue 12, Pages 2575-2576 (June 2016) DOI: 10.1016/j.celrep.2016.06.012 Copyright © 2016 Terms and Conditions

Figure 1 Antisense RNA Regulation Can Reduce Leaky Gene Expression in Saccharomyces cerevisiae Huber et al. (2016) show that antisense regulation correlates with reduced leaky expression of genes in specific conditions, especially when transcripts overlap the sense transcript start site. This not only results in more effective gene silencing but also can reduce heterogeneity in transcript levels between cells (“noise”). Cell Reports 2016 15, 2575-2576DOI: (10.1016/j.celrep.2016.06.012) Copyright © 2016 Terms and Conditions