The Balancing Act of Neutrophils Bart W. Bardoel, Elaine F. Kenny, Gabriel Sollberger, Arturo Zychlinsky  Cell Host & Microbe  Volume 15, Issue 5, Pages 526-536 (May 2014) DOI: 10.1016/j.chom.2014.04.011 Copyright © 2014 Elsevier Inc. Terms and Conditions

Figure 1 The Development of Neutrophils from Hematopoietic Stem Cells Precursor development and terminal differentiation of neutrophils from hematopoietic stem cells. Essential transcription factors are highlighted in pink. HSC, hematopoietic stem cell; MPP, multipotent precursor; EMP, erythromyeloid precursor; LMP, lymphomyeloid precursor; GMP, granulocyte-macrophage precursor. Please refer to the Development of Neutrophils section for details. Adapted from Borregaard (2010). Cell Host & Microbe 2014 15, 526-536DOI: (10.1016/j.chom.2014.04.011) Copyright © 2014 Elsevier Inc. Terms and Conditions

Figure 2 Schematic Overview of ROS Production in the Phagosome MPO is stored in azurophilic granules within the neutrophil. After phagocytosis, the granules fuse and release MPO into the phagosome. The NADPH oxidase complex generates superoxide that is converted into hydrogen peroxide. MPO uses hydrogen peroxide to catalyze the production of potent antimicrobial molecules, such as hypochlorous acid. Cell Host & Microbe 2014 15, 526-536DOI: (10.1016/j.chom.2014.04.011) Copyright © 2014 Elsevier Inc. Terms and Conditions

Figure 3 The Good and Bad Sides of Neutrophil Activation The three main antimicrobial functions of neutrophils and their positive (green) and negative (red) aspects for the host. Cell Host & Microbe 2014 15, 526-536DOI: (10.1016/j.chom.2014.04.011) Copyright © 2014 Elsevier Inc. Terms and Conditions