Analysis of longitudinal quality-of-life data in high-risk operable patients with lung cancer: Results from the ACOSOG Z4032 (Alliance) multicenter randomized.

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Presentation transcript:

Analysis of longitudinal quality-of-life data in high-risk operable patients with lung cancer: Results from the ACOSOG Z4032 (Alliance) multicenter randomized trial Hiran C. Fernando, MD, Rodney J. Landreneau, MD, Sumithra J. Mandrekar, PhD, Francis C. Nichols, MD, Thomas A. DiPetrillo, MD, Bryan F. Meyers, MD, Dwight E. Heron, MD, Shauna L. Hillman, MS, David R. Jones, MD, Sandra L. Starnes, MD, Angelina D. Tan, BS, Benedict D.T. Daly, MD, Joe B. Putnam, MD The Journal of Thoracic and Cardiovascular Surgery Volume 149, Issue 3, Pages 718-726 (March 2015) DOI: 10.1016/j.jtcvs.2014.11.003 Copyright © 2015 The American Association for Thoracic Surgery Terms and Conditions

Figure 1 Patient CONSORT diagram. SR, Sublobar resection; SRB, SR with brachytherapy; IRB, institutional review board; NSCLC, non–small cell lung cancer; T3N0, tumor stage 3, nodal involvement; T3, tumor stage 3; CT, computed tomography; QOL, quality of life. The Journal of Thoracic and Cardiovascular Surgery 2015 149, 718-726DOI: (10.1016/j.jtcvs.2014.11.003) Copyright © 2015 The American Association for Thoracic Surgery Terms and Conditions

Figure 2 Comparison of quality-of-life scores at each time point, by arm. SOBQ, (University of California, San Diego) shortness of breath questionnaire; SR, sublobar resection; SF36, 36-item short-form health survey. The Journal of Thoracic and Cardiovascular Surgery 2015 149, 718-726DOI: (10.1016/j.jtcvs.2014.11.003) Copyright © 2015 The American Association for Thoracic Surgery Terms and Conditions

Figure 3 Kaplan-Meier curve for overall survival by median values of baseline SOBQ scores. HR, Hazard ratio; SOBQ, (University of California, San Diego) shortness of breath questionnaire; CI, confidence interval. The Journal of Thoracic and Cardiovascular Surgery 2015 149, 718-726DOI: (10.1016/j.jtcvs.2014.11.003) Copyright © 2015 The American Association for Thoracic Surgery Terms and Conditions

Overall survival after sublobar resection, comparing patients with low and high baseline dyspnea scores. The Journal of Thoracic and Cardiovascular Surgery 2015 149, 718-726DOI: (10.1016/j.jtcvs.2014.11.003) Copyright © 2015 The American Association for Thoracic Surgery Terms and Conditions