The Incognito Journey of a Regulatory B Cell Claudia Mauri, Paul A. Blair  Immunity  Volume 41, Issue 6, Pages 878-880 (December 2014) DOI: 10.1016/j.immuni.2014.12.003 Copyright © 2014 Elsevier Inc. Terms and Conditions

Figure 1 Hypothetical Breg Cell Development Pathways IL-10+ T2-MZP or B10 Breg cells have been suggested to develop from the immature B cell pool in the spleen after CD40 and TLR stimulation. The data in Matsumoto et al. (2014) allows the hypothesis that, with additional IFN-α and TLR9 stimulation, these cells can further develop to become regulatory plasmablasts after recirculation to lymph nodes, or even directly in the spleen. Alternatively, regulatory plasmablasts might develop from mature B cells in the lymph nodes during inflammation without the need for a regulatory B cell precursor. The final fate of regulatory plasmablasts is unclear and they might become long-lived plasma cells. Immunity 2014 41, 878-880DOI: (10.1016/j.immuni.2014.12.003) Copyright © 2014 Elsevier Inc. Terms and Conditions