Distinction between phyllodes tumor and fibroadenoma in breast ultrasound using deep learning image analysis Elina Stoffel, Anton S. Becker, Moritz C.

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Presentation transcript:

Distinction between phyllodes tumor and fibroadenoma in breast ultrasound using deep learning image analysis Elina Stoffel, Anton S. Becker, Moritz C. Wurnig, Magda Marcon, Soleen Ghafoor, Nicole Berger, Andreas Boss European Journal of Radiology Open Volume 5, Pages 165-170 (January 2018) DOI: 10.1016/j.ejro.2018.09.002 Copyright © 2018 The Authors Terms and Conditions

Fig. 1 Proposed integration of a deep learning based software into the clinical workflow. Deep learning image analysis has the ability to evaluate features, which are not perceptible to the human reader and may thus augment the evaluation of the radiologist. European Journal of Radiology Open 2018 5, 165-170DOI: (10.1016/j.ejro.2018.09.002) Copyright © 2018 The Authors Terms and Conditions

Fig. 2 When comparing the performance of human readers and DLS on the validation data set, the complimentary performance of the DLS with high sensitivity (p < 0.05 for all readers) but lower specificity is already evident (AUC reader 1 [red] = 0.60, reader 2 [green] = 0.77, reader 3 [dark blue] = 0.75 and reader 4 [light blue] = 0.74). Readers 1 to 4 represent radiologists from highest to lowest levels of experience, respectively. European Journal of Radiology Open 2018 5, 165-170DOI: (10.1016/j.ejro.2018.09.002) Copyright © 2018 The Authors Terms and Conditions

Fig. 3 Example of a true positive in both the DLS and readers. This large lesion exhibited irregular internal structure with cystic components and indistinct margins, which lead to the correct diagnosis of this PT by both the DLS and all 4 readers. European Journal of Radiology Open 2018 5, 165-170DOI: (10.1016/j.ejro.2018.09.002) Copyright © 2018 The Authors Terms and Conditions

Fig. 4 Example of a false positive of the DLS and a true negative from experienced readers. The ultrasound image depicts a FA that the DLS falsely interpreted as a PT, possibly due to the acoustic shadowing at the borders. Three readers identified this image as a probable, and one reader as a definite FA. European Journal of Radiology Open 2018 5, 165-170DOI: (10.1016/j.ejro.2018.09.002) Copyright © 2018 The Authors Terms and Conditions

Fig. 5 Example of a true negative from the DLS and false positive from the readers. This FA from the validation set (i.e. withheld during training of the DLS) was correctly identified by the DLS, however, the readers falsely interpreted it as a probable PT (and one reader rated it as indeterminate). European Journal of Radiology Open 2018 5, 165-170DOI: (10.1016/j.ejro.2018.09.002) Copyright © 2018 The Authors Terms and Conditions

Fig. 6 ROC curves of Readers 1–4 (top left to bottom right) showing a non-significant tendency of improved performance in three out of the four readers (pmin = 0.07) when taking the DLS prediction into consideration (solid line), compared to the radiologists’ judgement alone (dashed line). European Journal of Radiology Open 2018 5, 165-170DOI: (10.1016/j.ejro.2018.09.002) Copyright © 2018 The Authors Terms and Conditions