CRISPR genome-editing: A medical revolution

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Presentation transcript:

CRISPR genome-editing: A medical revolution James R. Butler, MD, A. Joseph Tector, MD, PhD The Journal of Thoracic and Cardiovascular Surgery Volume 153, Issue 2, Pages 488-491 (February 2017) DOI: 10.1016/j.jtcvs.2016.08.067 Copyright © 2016 The American Association for Thoracic Surgery Terms and Conditions

Figure 1 CRISPR/Cas9 genome-editing is revolutionizing the production of model animals. This system creates targeted genome modifications by directing a nuclease (protein capable of creating double-strand breaks in DNA) to a specific genomic sequence by RNA-guided homology. Because NHEJ is an error-prone process of DNA repair, silencing mutations often are introduced. After a genetically modified cell is created, clonal model animals may be created through somatic cell nuclear transfer. NHEJ, Nonhomologous end joining. The Journal of Thoracic and Cardiovascular Surgery 2017 153, 488-491DOI: (10.1016/j.jtcvs.2016.08.067) Copyright © 2016 The American Association for Thoracic Surgery Terms and Conditions

CRISPR/Cas9 genome-editing is revolutionizing the production of model animals. The Journal of Thoracic and Cardiovascular Surgery 2017 153, 488-491DOI: (10.1016/j.jtcvs.2016.08.067) Copyright © 2016 The American Association for Thoracic Surgery Terms and Conditions