Fig. 3 Fbln4E57K/E57K mice develop large artery stiffness and systolic hypertension. Fbln4E57K/E57K mice develop large artery stiffness and systolic hypertension.

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Fig. 3 Fbln4E57K/E57K mice develop large artery stiffness and systolic hypertension. Fbln4E57K/E57K mice develop large artery stiffness and systolic hypertension. Pressure-diameter relationships of ascending aorta (A) and carotid arteries (B) from 3- to 6-month-old Fbln4E57K/E57K male mice and littermates (Fbln4+/+ and Fbln4+/E57K). At each pressure, the vessel outer diameter was compared to that of WT vessels using two-way analysis of variance (ANOVA) with Tukey’s multiple comparisons test. n = 7 to 10 for ascending aorta except for aneurysmal Fbln4E57K/E57K, where n = 3 (A) and 8 to 9 (B) for carotid arteries. Arterial systolic blood pressure (SBP) (C), diastolic blood pressure (DBP) (D), and pulse pressure (PP) (E) of 3- to 4-month-old Fbln4E57K/E57K male and female mice and littermates. PP was calculated as the difference between measured SBP and DBP. Pressure was compared among all genotypes using one-way ANOVA with Tukey’s multiple comparisons test. n = 10 to 12 per genotype. (F) Heart weight–to–body weight ratios between the three genotypes presented in two distinct age groups. At 6 to 7 months of age, mice with aortic root dilatation developed cardiac hypertrophy. Data are means ± SD. *P < 0.05, ****P < 0.0001. Carmen M. Halabi et al. Sci Adv 2017;3:e1602532 Published by AAAS