Differential effects of atorvastatin on autophagy in ischemic and nonischemic myocardium in Ossabaw swine with metabolic syndrome Ashraf A. Sabe, MD,

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Presentation transcript:

Differential effects of atorvastatin on autophagy in ischemic and nonischemic myocardium in Ossabaw swine with metabolic syndrome Ashraf A. Sabe, MD, Nassrene Y. Elmadhun, MD, Ahmed A. Sadek, BS, Louis M. Chu, MD, Cesario Bianchi, MD, PhD, Frank W. Sellke, MD The Journal of Thoracic and Cardiovascular Surgery Volume 148, Issue 6, Pages 3172-3178 (December 2014) DOI: 10.1016/j.jtcvs.2014.07.104 Copyright © 2014 The American Association for Thoracic Surgery Terms and Conditions

Figure 1 Schematic model of autophagy in the setting of cardiomyocyte stress. The Journal of Thoracic and Cardiovascular Surgery 2014 148, 3172-3178DOI: (10.1016/j.jtcvs.2014.07.104) Copyright © 2014 The American Association for Thoracic Surgery Terms and Conditions

Figure 2 Weight increase (kilograms) and blood glucose after dextrose challenge at terminal procedure: Weight change and blood glucose level ± standard error of the mean. Weights were measured before ameroid placement and again before harvest. Blood glucose level measured 30 minutes after intravenous dextrose challenge (50 mg/kg). One-way analysis of variance performed to determine P value. Bonferroni multiple comparison tests were performed. OC, Regular diet control group; OHC, high cholesterol control group; OHCS, high cholesterol control group supplemented with daily oral atorvastatin. The Journal of Thoracic and Cardiovascular Surgery 2014 148, 3172-3178DOI: (10.1016/j.jtcvs.2014.07.104) Copyright © 2014 The American Association for Thoracic Surgery Terms and Conditions

Figure 3 Protein expression in myocardium fold change ± standard error of the mean compared with OC. One-way analysis of variance performed to determine P value. Bonferroni multiple comparison tests were performed. LAMP-2, Lysosome-associated membrane protein 2; LC3B-I, light chain 3B-I; LC3B-II, light chain 3B-II; mTOR, mammalian target of rapamycin; OC, regular diet control group; OHC, high cholesterol control group; OHCS, high cholesterol control group supplemented with daily oral atorvastatin. The Journal of Thoracic and Cardiovascular Surgery 2014 148, 3172-3178DOI: (10.1016/j.jtcvs.2014.07.104) Copyright © 2014 The American Association for Thoracic Surgery Terms and Conditions