Laurence J. Egan Clinical Gastroenterology and Hepatology

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Presentation transcript:

Drug interactions in gastroenterology: Mechanisms, consequences, and how to avoid Laurence J. Egan Clinical Gastroenterology and Hepatology Volume 2, Issue 9, Pages 725-730 (September 2004) DOI: 10.1016/S1542-3565(04)00343-X Copyright © 2004 American Gastroenterological Association Terms and Conditions

Figure 1 The omeprazole-itraconazole interaction is caused by a pharmacokinetic mechanism at the level of itraconazole absorption. Clinical Gastroenterology and Hepatology 2004 2, 725-730DOI: (10.1016/S1542-3565(04)00343-X) Copyright © 2004 American Gastroenterological Association Terms and Conditions

Figure 2 The methotrexate-ibuprofen interaction is caused by a pharmacokinetic mechanism at the level of methotrexate excretion. Clinical Gastroenterology and Hepatology 2004 2, 725-730DOI: (10.1016/S1542-3565(04)00343-X) Copyright © 2004 American Gastroenterological Association Terms and Conditions

Figure 3 The cyclosporine-grapefruit juice interaction is caused by a pharmacokinetic mechanism at the level of cyclosporine first-pass metabolism. Clinical Gastroenterology and Hepatology 2004 2, 725-730DOI: (10.1016/S1542-3565(04)00343-X) Copyright © 2004 American Gastroenterological Association Terms and Conditions

Figure 4 The azathioprine-allopurinol interaction is caused by a pharmacokinetic mechanism at the level of azathioprine metabolism. Clinical Gastroenterology and Hepatology 2004 2, 725-730DOI: (10.1016/S1542-3565(04)00343-X) Copyright © 2004 American Gastroenterological Association Terms and Conditions

Figure 5 The warfarin-phenobarbital interaction is caused by a pharmacokinetic mechanism at the level of warfarin inactivation. Clinical Gastroenterology and Hepatology 2004 2, 725-730DOI: (10.1016/S1542-3565(04)00343-X) Copyright © 2004 American Gastroenterological Association Terms and Conditions

Figure 6 The warfarin-aspirin interaction is caused by a combination of pharmacodynamic mechanisms that result in greater anticoagulant effects. Clinical Gastroenterology and Hepatology 2004 2, 725-730DOI: (10.1016/S1542-3565(04)00343-X) Copyright © 2004 American Gastroenterological Association Terms and Conditions

Figure 7 The furosemide-indomethacin interaction is caused by a pharmacodynamic mechanism at the level of renal sodium handling. Clinical Gastroenterology and Hepatology 2004 2, 725-730DOI: (10.1016/S1542-3565(04)00343-X) Copyright © 2004 American Gastroenterological Association Terms and Conditions

Figure 8 The cause of the selegiline-meperidine interaction is obscure. Clinical Gastroenterology and Hepatology 2004 2, 725-730DOI: (10.1016/S1542-3565(04)00343-X) Copyright © 2004 American Gastroenterological Association Terms and Conditions