Effect of statins on atrial fibrillation after cardiac surgery: A duration- and dose-response meta-analysis Wendy T. Chen, PharmD, Guru M. Krishnan,

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Effect of statins on atrial fibrillation after cardiac surgery: A duration- and dose-response meta-analysis Wendy T. Chen, PharmD, Guru M. Krishnan, MD, Nitesh Sood, MD, Jeffrey Kluger, MD, Craig I. Coleman, PharmD The Journal of Thoracic and Cardiovascular Surgery Volume 140, Issue 2, Pages 364-372 (August 2010) DOI: 10.1016/j.jtcvs.2010.02.042 Copyright © 2010 The American Association for Thoracic Surgery Terms and Conditions

Figure 1 Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) flow chart. RCT, Randomized, controlled trial; CTS, cardiothoracic surgery. The Journal of Thoracic and Cardiovascular Surgery 2010 140, 364-372DOI: (10.1016/j.jtcvs.2010.02.042) Copyright © 2010 The American Association for Thoracic Surgery Terms and Conditions

Figure 2 Statins' effects on postoperative atrial fibrillation (A), intensive care unit stay (B), and total hospital stay (C). All pooled results were calculated with DerSimonian and Laird random-effects model. RR, Relative risk; CI, confidence interval; WMD, weighted mean difference. The Journal of Thoracic and Cardiovascular Surgery 2010 140, 364-372DOI: (10.1016/j.jtcvs.2010.02.042) Copyright © 2010 The American Association for Thoracic Surgery Terms and Conditions

Figure 3 Risk ratio (RR) of postoperative atrial fibrillation associated with duration of preoperative statin use. Greater weight of study corresponds to larger area of circle and to greater contribution of study to overall pooled effect. Superimposed line was obtained by conducting random-effects metaregression analysis with restricted maximum likelihood method to estimate residual variance resulting from heterogeneity. The Journal of Thoracic and Cardiovascular Surgery 2010 140, 364-372DOI: (10.1016/j.jtcvs.2010.02.042) Copyright © 2010 The American Association for Thoracic Surgery Terms and Conditions