Shirley Yeung, Catherine Salvato INHIBIN AND OREXIN! Shirley Yeung, Catherine Salvato

INHIBIN: Alpha and Beta glycoprotein gonads sertoli cells (male) granulosa (female - B) placenta target: pituitary gland

Source of Control production caused by: FSH FSH (follicle stimulating hormone) feedback hormone production ceased by: activin counteraction

Role in the Body ALPHA BETA suppresses FSH / FSHR progesterone regulates hypothalamic-pituitary-gonadal axis (childhood + puberty - females)

Hypo and Hyper-secretion both hyposecretion and hypersecretion are effects of FSH hypo/hyper-secretion affects growth - puberty Analogy INhibin INHIBITS INner child

Orexin! Produced and received in hypothalamus above pituitary gland Peptide hormone (amino acid) Controlled by leptin, glucose leptin: suppresses hunger glucose: instant energy

Maintenance of Homeostasis Wakefulness keeps you alert maintains long, consolidated walking period Appetite promotes desire for food Sleep deprivation = more hunger Some correlation with mood high = happiness low = sadness

Analogy Orexin is your inner alarm clock! The “O” is shaped like a clock that keeps you awake for the day :D (rexin)

Consequences HYPER-secretion: insomnia difficulty sleeping, even when tired can be caused by stress HYPO-secretion: narcolepsy loss of control over sleep excessive tiredness, sudden bouts of sleep

Bibliography: Inhibin "Activin and Inhibin Effects." Activin and Inhibin Effects. N.p., n.d. Web. 11 Feb. 2014. <http://www.cytochemistry.net/childs/Gon4.htm>. Chada, M., R. Prusa, J. Bronsky, M. Pechova, K. Kotaska, and L. Lisa. "PubMed." National Center for Biotechnology Information. U.S. National Library of Medicine, n.d. Web. 11 Feb. 2014. <http://www.ncbi.nlm.nih.gov/pubmed/12790766>. De Jong, FH. "PubMed." National Center for Biotechnology Information. U.S. National Library of Medicine, n.d. Web. 11 Feb. 2014. <http://www.ncbi.nlm.nih.gov/pubmed/3282246>. Ibanez, L., C. Valls, M. Cols, A. Ferrer, M.V. Marcos, and F. De Zegher. "PubMed." National Center for Biotechnology Information. U.S. National Library of Medicine, n.d. Web. 11 Feb. 2014. <http://www.ncbi.nlm.nih.gov/pubmed/11994329>. Lu, C., W. Yang, T. Liu, J. Yang, P. Tan, L. Li, X. Hu, C. Fan, Z. Hu, and Y. Liu. "PubMed." National Center for Biotechnology Information. U.S. National Library of Medicine, n.d. Web. 11 Feb. 2014. <http://www.ncbi.nlm.nih.gov/pubmed/18992787>.

Bibliography: Orexin Works Cited: Blouin, Ashley. "Abstract." National Center for Biotechnology Information. U.S. National Library of Medicine, 3 May 2013. Web. 11 Feb. 2014. <http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3595130/>. "Genes and mapped phenotypes." National Center for Biotechnology Information. U.S. National Library of Medicine, n.d. Web. 11 Feb. 2014. <http://www.ncbi.nlm.nih.gov/gene/3060>. "Insomnia (Chronic and Acute Insomnia) Causes and Symptoms." WebMD. WebMD, n.d. Web. 10 Feb. 2014. <http://www.webmd.com/sleep-disorders/guide/insomnia-symptoms-and-causes>. "Narcolepsy Fact Sheet." : National Institute of Neurological Disorders and Stroke (NINDS). N.p., n.d. Web. 9 Feb. 2014. <http://www.ninds.nih.gov/disorders/narcolepsy/detail_narcolepsy.htm>. "Orexin receptor antagonists: A new class of sleeping pill." National Sleep Foundation. N.p., n.d. Web. 11 Feb. 2014. <http://www.sleepfoundation.org/article/orexin-receptor-antagonists-new-class-sleeping-pill>. "Result Filters." National Center for Biotechnology Information. U.S. National Library of Medicine, n.d. Web. 11 Feb. 2014. <http://www.ncbi.nlm.nih.gov/pubmed/12450737>. "Result Filters." National Center for Biotechnology Information. U.S. National Library of Medicine, n.d. Web. 11 Feb. 2014. <http://www.ncbi.nlm.nih.gov/pubmed/19549926>. Tsujino, Natsuko , and Takeshi Sakurai. "Orexin/Hypocretin: A Neuropeptide at the Interface of Sleep, Energy Homeostasis, and Reward System." Pharmological Reviews. American Society for Pharmacology and Experimental Therapeutics, n.d. Web. 11 Feb. 2014. <http://pharmrev.aspetjournals.org/content/61/2/162.full>.