Uncoupling of Myocardial β-Adrenergic Receptor Signaling During Coronary Artery Bypass Grafting: The Role of GRK2 Christian F. Bulcao, MD, Prakash K.

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Uncoupling of Myocardial β-Adrenergic Receptor Signaling During Coronary Artery Bypass Grafting: The Role of GRK2 Christian F. Bulcao, MD, Prakash K. Pandalai, MD, Karen M. D'Souza, PhD, Walter H. Merrill, MD, Shahab A. Akhter, MD The Annals of Thoracic Surgery Volume 86, Issue 4, Pages 1189-1194 (October 2008) DOI: 10.1016/j.athoracsur.2008.05.042 Copyright © 2008 The Society of Thoracic Surgeons Terms and Conditions

Fig 1 Basal and β-agonist-stimulated myocardial sarcolemmal membrane adenylyl cyclase activity before (white bars) and after (black bars) cardiopulmonary bypass. *p < 0.05 between groups (n = 48 in each group). (ISO = isoproterenol; NaF = sodium fluoride.) The Annals of Thoracic Surgery 2008 86, 1189-1194DOI: (10.1016/j.athoracsur.2008.05.042) Copyright © 2008 The Society of Thoracic Surgeons Terms and Conditions

Fig 2 Myocardial sarcolemmal membrane β-adrenergic receptor density before (white bars) and after (black bars) cardiopulmonary bypass (CPB). There was no statistical difference between groups (n = 48 in each group performed in triplicate; p > 0.05). The Annals of Thoracic Surgery 2008 86, 1189-1194DOI: (10.1016/j.athoracsur.2008.05.042) Copyright © 2008 The Society of Thoracic Surgeons Terms and Conditions

Fig 3 Myocardial G protein-coupled receptor kinase-2 (GRK2) expression before (white bars) and after (black bars) cardiopulmonary bypass (CPB). There was no statistical difference between groups (p > 0.05). n = 48 in each group. (+ = positive control for GRK2.) The Annals of Thoracic Surgery 2008 86, 1189-1194DOI: (10.1016/j.athoracsur.2008.05.042) Copyright © 2008 The Society of Thoracic Surgeons Terms and Conditions

Fig 4 Myocardial G protein-coupled receptor kinase-2 (GRK2) activity before (white bars) and after (black bars) cardiopulmonary bypass (CPB). *p < 0.05 versus before cardiopulmonary bypass (n = 48 in each group). (Rho = rhodopsin.) The Annals of Thoracic Surgery 2008 86, 1189-1194DOI: (10.1016/j.athoracsur.2008.05.042) Copyright © 2008 The Society of Thoracic Surgeons Terms and Conditions

Fig 5 After cardiopulmonary bypass G protein-coupled receptor kinase-2 (GRK2) activity relative to before cardiopulmonary bypass (Pre-CPB). White bar is those with a left ventricular ejection fraction greater than 0.25 (n = 36); black bar is those with a left ventricular ejection fraction less 0.25 (n = 12). *p < 0.05. The Annals of Thoracic Surgery 2008 86, 1189-1194DOI: (10.1016/j.athoracsur.2008.05.042) Copyright © 2008 The Society of Thoracic Surgeons Terms and Conditions