Hajer GR et al. Atherosclerosis 2009;202:216-24

Slides:

Advertisements

Similar presentations

The concept of Diabetes & CV risk: A lifetime risk challenge Vascular function as an early sign of trouble: How can the inhibition of cholesterol absorption.

Advertisements

Weng TC, et al. J Clin Pharm Ther 2010;35:

RISK FACTORS FOR ATHEROSCLEROSIS IN OBESE CHILDREN  Dyslipidemia High triglycerides, VLDL Low HDL High small, dense LDL  Glucose intolerance, diabetes.

Slide Source: Lipid and Lipoprotein Parameters at Baseline and Drug Treatment: METEOR Trial Baseline, Mean (SD) Time-Weighted Average.

Effect of 21-day Holistic Therapy at “Our Native Village Eco Resorts” on Diabetes Mellitus as assessed by blood glucose levels and consumption of oral.

Lipoproteins/Particles

Philip J. Barter, et al. Circulation 2011;124:

Baseline Characteristics of Individuals From the General Population by Quartiles of Triglyceride Levels a Børge G. Nordestgaard, et al. JAMA 2007;298:

Baseline Characteristics of Cases, Controls, and Entire VA-HIT Population James D. Otvos, et al, Circulation 2006;113:

Yunoki K et al. Atherosclerosis 2011 Epub Apr 22.

Flow of Patients Through the Trial Nissen SE, et al. JAMA 2008;299:

Trial profile Prakash Deedwania, et al. Lancet 2006; 368:

The Influence of Pravastatin and Atorvastatin on Markers of Oxidative Stress in Hypercholesterolemic Humans Bonnie Ky, MD,* Anne Burke, MD,* Sotirios Tsimikas,

Parameters BD PP CP TC (mg. dl-l) ± * ± 5.8

Dufaux, International Journal of Sports Medicine, 1982 TRIGLYCERIDES & TRAINING Increase Decrease No Change Numbers of Studies.

M.Sc. in Pharmacy/Clinical Laboratory Sciences

Westerweel PE et al. Eur Heart J 2008;29:

Independent variables (baseline) Loge (HOMA-IR) b P

Krill oil supplementation lowers serum triglycerides without increasing low-density lipoprotein cholesterol in adults with borderline high or high triglyceride.

Switch from EFV plus ABC-3TC to EFV-TDF-FTC ROCKET-1 Trial

Baseline Characteristics of Women and Men in Whom Coronary Heart Disease Developed during Follow-up and Matched Controls - A Jennifer K. Pai et al. N.

WCC12-ABS-1469 P751 Influence of the concentration and molecular composition on the LDL and HDL functional characteristics in patients with the metabolic.

Clinical Characteristics

Switching the NRTI Backbone to Tenofovir DF-Emtricitabine TOTEM

Arterioscler Thromb Vasc Biol

Dyslipidemia and the Risk of Developing Hypertension in a Working‐Age Male Population by Toshiaki Otsuka, Hirotaka Takada, Yasuhiro Nishiyama, Eitaro Kodani,

Oxford Niacin Trial.

The ASSERT Study.

Effects of High Density Lipoprotein Raising Therapies on Cardiovascular Outcomes in Patients with Type 2 Diabetes Mellitus, with or without Renal Impairment:

Laboratory November 2017 End stage renal disease.

Laboratory 9- Week of November 2015

Figure 3. Severity of aortic atherosclerosis in apo-E −/− mice with CRF. Aortic plaque area fraction (A), aortic cholesterol content (B), and aortic root.

Figure 2. Plasma lipoprotein cholesterol in apo-E −/− mice with CRF

Fellström BC, et al. N Engl J Med 2009;360:1455-7

Selmer R, et al. Br J Clin Pharmacol 2009;67:355-62

INT-767 treatment prevents renal lipid accumulation in diabetic DBA/2J mice. INT-767 treatment prevents renal lipid accumulation in diabetic DBA/2J mice.

Marina Cuchel, Dirk J. Blom, Maurizio R. Averna

Volume 141, Issue 3, Pages e4 (September 2011)

Subject Characteristics

Sudhop T. et al. J Lipid Res 2009 Apr 20 [Epub ahead of print]

Baseline Characteristics, Values at 24-Month Follow-up, and Changes from Baseline* - Part I John J.P. Kastelein, et al. N Engl J Med 2007;356: online.

Body mass, BMI, plasma lipids, lipoproteins, and glucose homeostasis at baseline, and following placebo and rosuvastatin periods Dmitri Sviridov et al.

Flow of Patients Through the Trial

Receiver operating characteristic analyses showing area under the curves with reference to 2-hour OGTT (A,B) and fasting plasma glucose (C,D). HbA1c, glycated.

Flow of Patients Through Trial

Study Participant Flow

Baseline Characteristics of the Subjects*

Baseline characteristics for patients with diabetes in ASCOT-LLA Part I P.S. SEVER et al Diabetes Care 2005; 28: 1151–1157.

Baseline Demographic Characteristics of Adults With Diagnosed Heart Failure and Eligible to Receive Lipid-Lowering Therapy Alan S. Go, et al.

Tremblay AJ. Et al. J Lipid Res 2009 Mar 22 [Epub ahead of print]

Participation in Japanese Primary Prevention of Atherosclerosis With Aspirin for Diabetes (JPAD) Trial Hisao Ogawa et al. JAMA 2008;300:

Duality of statin action on lipoprotein subpopulations in the mixed dyslipidemia of metabolic syndrome: Quantity vs quality over time and implication.

Disposition of Patients in the Atherogenic Dyslipidemia Study

(A) Low-density lipoprotein-cholesterol (LDL-C) values at baseline and after treatment with anagliptin in 20 participants at 12 and 24 weeks. (A) Low-density.

Baseline Lipid Parameters and Characteristics Among 3110 Men According to Quintiles of Total Cholesterol Ruben O. Halperin et al, Hypertension 2006;47;45-50.

RECORD Study: Enrollment and Outcomes

VK2809 in NAFLD: a phase 2 study

RADIANCE 2 Study: Trial proﬁle

PROSPER: trial design

Baseline characteristics of the 1,842 men without coronary heart disease and the 230 men with a first coronary heart disease event during the 13-year.

Titration activities from baseline up to 6 and 12 months follow-up in nurse-coordinated care (NCC) versus usual care patients. X-as: patients (percentage),

Relationship between selected metabolic parameters and the primary composite end point. Relationship between selected metabolic parameters and the primary.

Correlation between progranulin (dependent variable) and CKD stage adjusted for age and sex, as well as DBP, WHR, triglycerides, HDL cholesterol, LDL cholesterol,

Flow of study participants

Mean fasting C-peptide levels (for all subjects [A]) and mean peak C-peptide levels (all subjects [B], adolescents [C], and adults [D])after mixed-meal.

DPP4 release of explants obtained from adipose tissue of lean controls and obese patients before and after bariatric surgery, and linear correlation with.

Effects of pterosin A on serum levels of lipid, blood urea nitrogen (BUN), creatinine, aspartate aminotransferase (AST), and alanine aminotransferase (ALT)

Individual lipid measures for high-carbohydrate (n=10) and low-carbohydrate (n=10) ultra-endurance athletes. Individual lipid measures for high-carbohydrate.

© The Author(s) Published by Science and Education Publishing.

Changes of major clinical and biochemical characteristics at baseline and during follow-up in different groups. Changes of major clinical and biochemical.

Presentation transcript:

Hajer GR et al. Atherosclerosis 2009;202:216-24

Baseline characteristics of study subjects Hajer GR et al. Atherosclerosis 2009;202:216-24

Fasting lipid parameters at baseline and after both treatment periods Hajer GR et al. Atherosclerosis 2009;202:216-24

Change of lipid levels in plasma and lipid fractions during 8 h after oral fat load Hajer GR et al. Atherosclerosis 2009;202:216-24

Postprandial triglyceride content in lipoprotein fractions Hajer GR et al. Atherosclerosis 2009;202:216-24

Postprandial cholesterol content in lipoprotein fractions Hajer GR et al. Atherosclerosis 2009;202:216-24

Postprandial ApoB content in lipoprotein fractions Hajer GR et al. Atherosclerosis 2009;202:216-24