Identification of IL18RAP/IL18R1 and IL12B as Leprosy Risk Genes Demonstrates Shared Pathogenesis between Inflammation and Infectious Diseases Hong Liu,

Slides:

Advertisements

Similar presentations

Previous Estimates of Mitochondrial DNA Mutation Level Variance Did Not Account for Sampling Error: Comparing the mtDNA Genetic Bottleneck in Mice and.

Advertisements

Gene Preference in Maple Syrup Urine Disease Mary M. Nellis, Dean J. Danner The American Journal of Human Genetics Volume 68, Issue 1, Pages (January.

The IL-33-ST2L Pathway Is Associated with Coronary Artery Disease in a Chinese Han Population Xin Tu, Shaofang Nie, Yuhua Liao, Hongsong Zhang, Qian.

The first report of detecting the blaSIM-2 gene and determining the complete sequence of the SIM-encoding plasmid F. Sun, D. Zhou, Q. Wang, J. Feng,

Hepatitis B immunoglobulin injection in pregnancy to interrupt hepatitis B virus mother- to-child transmission—a meta-analysis Zhongjie Shi, Xiaomao Li,

A Single SNP in an Evolutionary Conserved Region within Intron 86 of the HERC2 Gene Determines Human Blue-Brown Eye Color Richard A. Sturm, David L.

Association Analyses Identify Three Susceptibility Loci for Vitiligo in the Chinese Han Population Xian-Fa Tang, Zheng Zhang, Da-Yan Hu, Ai-E Xu, Hai-Sheng.

A Common Variant in SLC8A1 Is Associated with the Duration of the Electrocardiographic QT Interval Jong Wook Kim, Kyung-Won Hong, Min Jin Go, Sung Soo.

Differences in asthma genetics between Chinese and other populations

A Novel Linkage to Generalized Vitiligo on 4q13-q21 Identified in a Genomewide Linkage Analysis of Chinese Families Jian-Jun Chen, Wei Huang, Jin-Ping.

Comprehensively Evaluating cis-Regulatory Variation in the Human Prostate Transcriptome by Using Gene-Level Allele-Specific Expression Nicholas B. Larson,

Genetic Structure of the Han Chinese Population Revealed by Genome-wide SNP Variation Jieming Chen, Houfeng Zheng, Jin-Xin Bei, Liangdan Sun, Wei-hua.

Epigenome-Wide Association Analysis Identified Nine Skin DNA Methylation Loci for Psoriasis Fusheng Zhou, Wenjun Wang, Changbing Shen, Hui Li, Xianbo.

Copy-Number Mutations on Chromosome 17q24. 2-q24

Outcomes of per-oral endoscopic myotomy for treatment of esophageal achalasia with a median follow-up of 49 months Quan-Lin Li, MD, Qiu-Ning Wu, MD,

Volume 74, Issue 6, Pages (December 2018)

Common Variants of Large Effect in F12, KNG1, and HRG Are Associated with Activated Partial Thromboplastin Time Lorna M. Houlihan, Gail Davies, Albert.

Genome-wide Association and Follow-Up Replication Studies Identified ADAMTS18 and TGFBR3 as Bone Mass Candidate Genes in Different Ethnic Groups Dong-Hai.

Differences in asthma genetics between Chinese and other populations

Association of the CHRNA3 Locus with Lung Cancer Risk and Prognosis in Chinese Han Population Xiaomin Niu, MD, Zhiwei Chen, MD, PhD, Shengping Shen,

A Single SNP in an Evolutionary Conserved Region within Intron 86 of the HERC2 Gene Determines Human Blue-Brown Eye Color Richard A. Sturm, David L.

A Comprehensive cis-eQTL Analysis Revealed Target Genes in Breast Cancer Susceptibility Loci Identified in Genome-wide Association Studies Xingyi Guo,

Mutations in PADI6 Cause Female Infertility Characterized by Early Embryonic Arrest Yao Xu, Yingli Shi, Jing Fu, Min Yu, Ruizhi Feng, Qing Sang, Bo Liang,

The first report of detecting the blaSIM-2 gene and determining the complete sequence of the SIM-encoding plasmid F. Sun, D. Zhou, Q. Wang, J. Feng,

Prevalence, risk factors, outcomes, and molecular epidemiology of mcr-1-positive Enterobacteriaceae in patients and healthy adults from China: an epidemiological.

The HLA Alleles B and DRB1

Missense Variants in HIF1A and LACC1 Contribute to Leprosy Risk in Han Chinese Dong Wang, Yu Fan, Mahadev Malhi, Rui Bi, Yong Wu, Min Xu, Xiu-Feng Yu,

PheWAS and Beyond: The Landscape of Associations with Medical Diagnoses and Clinical Measures across 38,662 Individuals from Geisinger Anurag Verma,

10 Years of GWAS Discovery: Biology, Function, and Translation

A 3.4-kb Copy-Number Deletion near EPAS1 Is Significantly Enriched in High-Altitude Tibetans but Absent from the Denisovan Sequence Haiyi Lou, Yan Lu,

Z. Wang, Z. Cui, Y. Li, T. Hou, X. Liu, Y. Xi, Y. Liu, H. Li, Q. He

Inversa Acne (Hidradenitis Suppurativa): A Case Report and Identification of the Locus at Chromosome 1p21.1–1q25.3 Min Gao, Pei-Guang Wang, Yong Cui,

Transethnic Genetic-Correlation Estimates from Summary Statistics

Six Mutations in AAGAB Confirm Its Pathogenic Role in Chinese Punctate Palmoplantar Keratoderma Patients Hongzhou Cui, Min Gao, Wenjun Wang, Ruo Xiao,

Identification of a Genetic Locus for Ichthyosis Vulgaris on Chromosome 10q22.3– q24.2 Ping Liu, Qingyu Yang, Xu Wang, Aiping Feng, Tao Yang, Rong Yang,

Genomic Dissection of Population Substructure of Han Chinese and Its Implication in Association Studies Shuhua Xu, Xianyong Yin, Shilin Li, Wenfei Jin,

Fine Mapping and Identification of BMI Loci in African Americans

Meta-analysis of Correlated Traits via Summary Statistics from GWASs with an Application in Hypertension Xiaofeng Zhu, Tao Feng, Bamidele O. Tayo, Jingjing.

Sherlock: Detecting Gene-Disease Associations by Matching Patterns of Expression QTL and GWAS Xin He, Chris K. Fuller, Yi Song, Qingying Meng, Bin Zhang,

Sang Hong Lee, Naomi R. Wray, Michael E. Goddard, Peter M. Visscher

Catarina D. Campbell, Nick Sampas, Anya Tsalenko, Peter H

X-Linked Congenital Hypertrichosis Syndrome Is Associated with Interchromosomal Insertions Mediated by a Human-Specific Palindrome near SOX3 Hongwen.

Zhihong Zhu, Andrew Bakshi, Anna A. E

A Variant in LIN28B Is Associated with 2D:4D Finger-Length Ratio, a Putative Retrospective Biomarker of Prenatal Testosterone Exposure Sarah E. Medland,

Five Years of GWAS Discovery

Amino Acid Variants of HLA-DRB1 Confer Susceptibility to Dapsone Hypersensitivity Syndrome in Addition to HLA-B*13:01 Zhenhua Yue, Yonghu Sun, Chuan.

Dan-Yu Lin, Zheng-Zheng Tang The American Journal of Human Genetics

Distribution of Measured GFR in Apparently Healthy Chinese Adults

Biallelic Mutations in PATL2 Cause Female Infertility Characterized by Oocyte Maturation Arrest Biaobang Chen, Zhihua Zhang, Xiaoxi Sun, Yanping Kuang,

A 3.4-kb Copy-Number Deletion near EPAS1 Is Significantly Enriched in High-Altitude Tibetans but Absent from the Denisovan Sequence Haiyi Lou, Yan Lu,

Genome-wide Association Study Reveals Multiple Nasopharyngeal Carcinoma- Associated Loci within the HLA Region at Chromosome 6p21.3 Ka-Po Tse, Wen-Hui.

Haploidentical/Mismatched Hematopoietic Stem Cell Transplantation without In Vitro T Cell Depletion for T Cell Acute Lymphoblastic Leukemia Yu Wang,

Association Analyses Identify Three Susceptibility Loci for Vitiligo in the Chinese Han Population Xian-Fa Tang, Zheng Zhang, Da-Yan Hu, Ai-E Xu, Hai-Sheng.

Joseph K. Pickrell The American Journal of Human Genetics

Identification of a Novel Locus for Marie Unna Hereditary Hypotrichosis to a 17.5 cM Interval at 1p21.1–1q21.3 Sen Yang, Min Gao, Yong Cui, Kai-Lin Yan,

A Genome-Wide Association Study of Basal Transepidermal Water Loss Finds that Variants at 9q34.3 Are Associated with Skin Barrier Function Manfei Zhang,

L-GATOR: Genetic Association Testing for a Longitudinally Measured Quantitative Trait in Samples with Related Individuals Xiaowei Wu, Mary Sara McPeek

Xiang Wan, Can Yang, Qiang Yang, Hong Xue, Xiaodan Fan, Nelson L. S

P Combined Molecular and Radiological Evaluation Unveils Three Subtypes of Disease Progression to a Third Generation EGFR TKI Y. Zhang, Q. Zhou,

Pleiotropic Effects of Trait-Associated Genetic Variation on DNA Methylation: Utility for Refining GWAS Loci Eilis Hannon, Mike Weedon, Nicholas Bray,

Yu Zhang, Tianhua Niu, Jun S. Liu

Allogeneic Peripheral Blood Stem Cell Transplantation is a Promising and Safe Choice for the Treatment of Refractory/Relapsed Acute Myelogenous Leukemia,

Evidence for a Novel Psoriasis Susceptibility Locus at 9q33–9q34 in Chinese Hans Liang-Dan Sun, Wei Li, Sen Yang, Xing Fan, Kai-Lin Yan, Yan-Hua Liang,

Common Variants of Large Effect in F12, KNG1, and HRG Are Associated with Activated Partial Thromboplastin Time Lorna M. Houlihan, Gail Davies, Albert.

Sarah E. Medland, Dale R. Nyholt, Jodie N. Painter, Brian P

An Osteoporosis Risk SNP at 1p36

A Population-Based Study of Acquired Bilateral Nevus-of-Ota-Like Macules in Shanghai, China Bei-Qing Wang, Zheng-Yu Shen, Ye Fei, Hong Li, Jian-Hang.

A Novel Linkage to Generalized Vitiligo on 4q13-q21 Identified in a Genomewide Linkage Analysis of Chinese Families Jian-Jun Chen, Wei Huang, Jin-Ping.

Zuoheng Wang, Mary Sara McPeek The American Journal of Human Genetics

Epidemiologic data of renal diseases from a single unit in China: Analysis based on 13,519 renal biopsies Lei-Shi Li, Zhi-Hong Liu Kidney International

Presentation transcript:

Identification of IL18RAP/IL18R1 and IL12B as Leprosy Risk Genes Demonstrates Shared Pathogenesis between Inflammation and Infectious Diseases Hong Liu, Astrid Irwanto, Hongqing Tian, Xi'an Fu, Yongxiang Yu, Gongqi Yu, Huiqi Low, Tongsheng Chu, Yi Li, Benqing Shi, Mingfei Chen, Yonghu Sun, Chunying Yuan, Nan Lu, Jiabao You, Fangfang Bao, Jinghui Li, Jian Liu, Huaxu Liu, Dianchang Liu, Xiulu Yu, Lin Zhang, Qing Yang, Na Wang, Guiye Niu, Shanshan Ma, Yan Zhou, Chuan Wang, Shumin Chen, Xuejun Zhang, Jianjun Liu, Furen Zhang The American Journal of Human Genetics Volume 91, Issue 5, Pages 935-941 (November 2012) DOI: 10.1016/j.ajhg.2012.09.010 Copyright © 2012 The American Society of Human Genetics Terms and Conditions

Figure 1 Regional Association Plots of rs2058660 and rs6871626 The p values of SNPs (shown as −log10p) (y axis) are plotted against their map positions (x axis). The color of each SNP spot reflects its r2 with the confirmed SNP within each locus. The confirmed SNP, the top SNP, and previously reported SNPs of each locus are all in pink and are labeled with arrows. Estimated recombination rates (based on the combined CHB [Han Chinese in Beijing, China] and JPT [Japanese in Tokyo, Japan] samples from the 1000 Genomes Project) are plotted in light blue. Gene annotations were adapted from the UCSC Genome Browser (see Web Resources). (A) rs2058660 on 2q12.1. (B) rs6871626 on 5q33.3. The American Journal of Human Genetics 2012 91, 935-941DOI: (10.1016/j.ajhg.2012.09.010) Copyright © 2012 The American Society of Human Genetics Terms and Conditions