Antibacterial activity, antibiotic retention, and infection resistance of a rifampin- impregnated gelatin-sealed Dacron graft Kevin Lachapelle, MD, Alan.

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Presentation transcript:

Antibacterial activity, antibiotic retention, and infection resistance of a rifampin- impregnated gelatin-sealed Dacron graft Kevin Lachapelle, MD, Alan M. Graham, MD, James F. Symes, MD Journal of Vascular Surgery Volume 19, Issue 4, Pages 675-682 (April 1994) DOI: 10.1016/S0741-5214(94)70041-9 Copyright © 1994 Society for Vascular Surgery and International Society for Cardiovascular Surgery, North American Chapter Terms and Conditions

Fig. 1 Mean concentrations of rifampin in serum, perigraft fluid, and homogenized aorta in four pigs after administration of 15 mg/kg intravenous rifampin. Journal of Vascular Surgery 1994 19, 675-682DOI: (10.1016/S0741-5214(94)70041-9) Copyright © 1994 Society for Vascular Surgery and International Society for Cardiovascular Surgery, North American Chapter Terms and Conditions

Fig. 2 Mean concentration of rifampin per gram of graft for 4 days after graft implantation in pigs. Journal of Vascular Surgery 1994 19, 675-682DOI: (10.1016/S0741-5214(94)70041-9) Copyright © 1994 Society for Vascular Surgery and International Society for Cardiovascular Surgery, North American Chapter Terms and Conditions

Fig. 3 Mean concentration of rifampin in serum and perigraft fluid for 4 days after graft implantation in pigs. Journal of Vascular Surgery 1994 19, 675-682DOI: (10.1016/S0741-5214(94)70041-9) Copyright © 1994 Society for Vascular Surgery and International Society for Cardiovascular Surgery, North American Chapter Terms and Conditions

Fig. 4 Infection rate in control pigs (group I), pigs given intravenous (IV) rifampin for 3 days after surgery (group II), and pigs with grafts impregnated with rifampin (group III). Journal of Vascular Surgery 1994 19, 675-682DOI: (10.1016/S0741-5214(94)70041-9) Copyright © 1994 Society for Vascular Surgery and International Society for Cardiovascular Surgery, North American Chapter Terms and Conditions