Pioglitazone reduces the adrenal androgen response to corticotropin-releasing factor without changes in ACTH release in hyperinsulinemic women with polycystic.

Slides:

Advertisements

Similar presentations

Validation of a prediction model for the follicle-stimulating hormone response dose in women with polycystic ovary syndrome Madelon van Wely, Ph.D.,

Advertisements

Specificity and predictive value of circulating testosterone assessed by tandem mass spectrometry for the diagnosis of polycystic ovary syndrome by the.

Clinically significant and sustained weight loss is achievable in obese women with polycystic ovary syndrome followed in a regular medical practice Lysanne.

Short-term therapy with combination dipeptidyl peptidase-4 inhibitor saxagliptin/metformin extended release (XR) is superior to saxagliptin or metformin.

Gaps in knowledge among physicians regarding diagnostic criteria and management of polycystic ovary syndrome Anuja Dokras, M.D., Ph.D., Shailly Saini,

The effect of cinnamon extract on insulin resistance parameters in polycystic ovary syndrome: a pilot study Jeff G. Wang, M.D., Richard A. Anderson,

Circulating inflammatory markers in polycystic ovary syndrome: a systematic review and metaanalysis Héctor F. Escobar-Morreale, M.D., Ph.D., Manuel Luque-Ramírez,

The relative effects of hormones and relationship factors on sexual function of women through the natural menopausal transition Lorraine Dennerstein,

Comparison of hormonal and metabolic markers after a high-fat, Western meal versus a low-fat, high-fiber meal in women with polycystic ovary syndrome

Risk of obstructive sleep apnea in obese and nonobese women with polycystic ovary syndrome and healthy reproductively normal women Babak Mokhlesi, M.D.,

Suppression and recovery of gonadotropin and steroid secretion by a gonadotropin- releasing hormone receptor antagonist in healthy women with normal ovulation.

Kalliopi Kotsa, M. D. , Ph. D. , Maria P. Yavropoulou, M. D

Michael M. Alper, M.D. Fertility and Sterility

Ovarian size and blood flow in women with polycystic ovary syndrome and their correlations with endocrine parameters Enrico Carmina, M.D., Francesco.

Michal Youngster, M. D. , Valerie L. Ward, M. D. , M. P. H. , Emily A

Dennis J. Hand, Ph. D. , Vanessa L. Short, Ph. D. , M. P. H. , Diane J

Gaps in knowledge among physicians regarding diagnostic criteria and management of polycystic ovary syndrome Anuja Dokras, M.D., Ph.D., Shailly Saini,

Possible metformin effect on adrenal androgens during pretreatment and IVF cycle in women with polycystic ovary syndrome Sigrun B. Kjøtrød, M.D., Arne.

Plasminogen activator inhibitor 1 and miscarriage after metformin treatment and laparoscopic ovarian drilling in patients with polycystic ovary syndrome

Serum insulin-like growth factor I (IGF-I) and IGF-binding protein 3 (IGFBP-3) in IVF patients with polycystic ovary syndrome: correlations with outcome

Can an educational DVD improve the acceptability of elective single embryo transfer? A randomized controlled study Nicole Hope, M.B., B.S., Hon., Luk.

Insulin resistance in oligomenorrheic infertile women with non-polycystic ovary syndrome Shirei Ohgi, M.D., Koji Nakagawa, M.D., Ph.D., Rieko Kojima,

Risk of depression and other mental health disorders in women with polycystic ovary syndrome: a longitudinal study Angela Kerchner, B.A., Whitney Lester,

Is the addition of metformin efficacious in the treatment of clomiphene citrate-resistant patients with polycystic ovary syndrome? A structured literature.

Obesity, weight loss, and the polycystic ovary syndrome: effect of treatment with diet and orlistat for 24 weeks on insulin resistance and androgen levels

Annette Kuhn, M. D. , Doris Bapst, Werner Stadlmayr, M. D

Expression of growth differentiation factor-9 and bone morphogenetic protein-15 in oocytes and cumulus granulosa cells of patients with polycystic ovary.

Rebecca A. Feldman, M. D. , Kathleen O'Neill, M. D. , Samantha F

Efficacy of metformin therapy in adolescent girls with androgen excess: relation to sex hormone–binding globulin and androgen receptor polymorphisms

Functional neuroimaging of emotional processing in women with polycystic ovary syndrome: a case-control pilot study Courtney A. Marsh, M.D., M.P.H.,

A randomized placebo-controlled study on the effects of pioglitazone on cortisol metabolism in polycystic ovary syndrome Dorte Glintborg, M.D., Ph.D.,

Evolutionary determinants of polycystic ovary syndrome: part 1

Letrozole versus combined metformin and clomiphene citrate for ovulation induction in clomiphene-resistant women with polycystic ovary syndrome: a randomized.

Specificity and predictive value of circulating testosterone assessed by tandem mass spectrometry for the diagnosis of polycystic ovary syndrome by the.

Serum soluble leptin receptor levels and free leptin index in women with polycystic ovary syndrome: relationship to insulin resistance and androgens

Pernille Fog Svendsen, M. D. , Michael Christiansen, M. D

Andrew C. Bjonnes, M.S., Richa Saxena, Ph.D., Corrine K. Welt, M.D.

Hyperglycemia Stimulates Activation of Nuclear Factor κB (NFκB) in Mononuclear Cells (MNC) of Women With Polycystic Ovary Syndrome (PCOS) F. Gonzalez,

Management of tubal ectopic pregnancy: methotrexate and salpingostomy are preferred to preserve fertility Stephanie Beall, M.D., Ph.D., Alan H. DeCherney,

Ovulation induction in women with polycystic ovary syndrome

Akanksha Mehta, M.D., Darius A. Paduch, M.D., Ph.D.

Increased secretion of amylin in women with polycystic ovary syndrome

Follicular loss in endoscopic surgery for ovarian endometriosis: quantitative and qualitative observations Daniela Romualdi, M.D., Ph.D., Gian Franco.

Fleur R. Cattrall, M. B. B. S. , Beverley J. Vollenhoven, M. B. B. S

Metformin treatment before and during in vitro fertilization or intracytoplasmic sperm injection in women with polycystic ovary syndrome: summary of a.

Metformin reduces serum müllerian-inhibiting substance levels in women with polycystic ovary syndrome after protracted treatment Richard Fleming, Ph.D.,

Banu Ucar, M. D. , Volkan Noyan, M. D. , Osman Caglayan, M. D

Simvastatin improves biochemical parameters in women with polycystic ovary syndrome: results of a prospective, randomized trial Antoni J. Duleba, M.D.,

Cameron Gilbert, M. Sc. , Maria Valois, M. D. , FRCPC, Ph. D

Impact of laparoscopic ovarian drilling on anti-Müllerian hormone levels and ovarian stromal blood flow using three-dimensional power Doppler in women.

Pregnancy outcome in infertile patients with polycystic ovary syndrome who were treated with metformin Samuel S. Thatcher, M.D., Ph.D., Elizabeth M.

Manuel Maliqueo, Ph. D. , Bárbara Echiburú, Ph. D

Effect of gonadotropin-releasing-hormone-induced hypogonadism on insulin action as assessed by euglycemic clamp studies in men Subodhsingh Chauhan, M.D.,

Fertility and Sterility: an evaluation

Obesity and androgens: facts and perspectives

Paolo Moghetti, M.D. Fertility and Sterility

Validation of a prediction model for the follicle-stimulating hormone response dose in women with polycystic ovary syndrome Madelon van Wely, Ph.D.,

Metformin effects on ovarian ultrasound appearance and steroidogenic function in normal-weight normoinsulinemic women with polycystic ovary syndrome:

Comparison of clomiphene citrate, metformin, or the combination of both for first-line ovulation induction and achievement of pregnancy in 154 women with.

Anna Maria Fulghesu, M. D. , Mario Ciampelli, M. D. , Giuseppe Muzj, M

Current evaluation of amenorrhea

Inappropriate gonadotropin secretion in polycystic ovary syndrome

Tsan-Hon Liou, M. D. , Ph. D. , Jen-Hung Yang, M. D. , Ph. D

Transforming growth factor-β1 and its receptor soluble endoglin are altered in polycystic ovary syndrome during controlled ovarian stimulation Reshef.

Adiponectin levels reflect the different phenotypes of polycystic ovary syndrome: study in normal weight, normoinsulinemic patients Artemis Karkanaki,

Decrease in adiponectin levels in women with polycystic ovary syndrome after an oral glucose tolerance test Dimitrios Panidis, M.D., Ph.D., Dimitrios.

Ongoing pregnancy rates in intrauterine insemination are affected by late follicular- phase progesterone levels Antonio Requena, M.D., María Cruz, Ph.D.,

Androgen responses to adrenocorticotropic hormone infusion among individual women with polycystic ovary syndrome Kevin H. Maas, M.D., Ph.D., Sandy Chuan,

Adolescent girls with polycystic ovary syndrome showing different phenotypes have a different metabolic profile associated with increasing androgen levels

Is there a role for diet in ameliorating the reproductive sequelae associated with chronic low-grade inflammation in polycystic ovary syndrome and obesity?

Presentation transcript:

Pioglitazone reduces the adrenal androgen response to corticotropin-releasing factor without changes in ACTH release in hyperinsulinemic women with polycystic ovary syndrome Daniela Romualdi, M.D., Maddalena Giuliani, M.D., Gaetano Draisci, M.D., Barbara Costantini, M.D., Francesca Cristello, M.D., Antonio Lanzone, M.D., Maurizio Guido, M.D., Ph.D. Fertility and Sterility Volume 88, Issue 1, Pages 131-138 (July 2007) DOI: 10.1016/j.fertnstert.2006.11.076 Copyright © 2007 American Society for Reproductive Medicine Terms and Conditions

FIGURE 1 ACTH and cortisol response to the CRF test in PCOS women before (squares/solid bars) and after (circles/clear bars) 4 months of pioglitazone therapy. Left panel: curves of secretion. Right panel: AUC values. Romualdi. HPA-axis in PCOS: effect of pioglitazone. Fertil Steril 2007. Fertility and Sterility 2007 88, 131-138DOI: (10.1016/j.fertnstert.2006.11.076) Copyright © 2007 American Society for Reproductive Medicine Terms and Conditions

FIGURE 2 Response to the CRF test in terms of A and P in PCOS women before (squares/solid bars) and after (circles/clear bars) treatment with pioglitazone. Left panel: curves of secretion. Right panel: AUC values. *P<.05 post-treatment vs. pre-treatment; **P<.01 post-treatment vs. pre-treatment. Romualdi. HPA-axis in PCOS: effect of pioglitazone. Fertil Steril 2007. Fertility and Sterility 2007 88, 131-138DOI: (10.1016/j.fertnstert.2006.11.076) Copyright © 2007 American Society for Reproductive Medicine Terms and Conditions