Comparing Two Means: Paired Data Section 10.3 Comparing Two Means: Paired Data

Section 10.3 Comparing Two Means: Paired Data After this section, you should be able to… ANALYZE the distribution of differences in a paired data set using graphs and summary statistics CONSTRUCT and interpret a confidence interval for a mean difference. PERFORM significance tests about a mean difference. DETERMINE when it is appropriate to use paired t procedures vs. two sample t procedures.

Inference for Means: Paired Data Study designs that involve making two observations on the same individual, or one observation on each of two similar individuals, result in paired data. When paired data result from measuring the same quantitative variable twice, we can make comparisons by analyzing the differences in each pair. If the conditions for inference are met, we can use one-sample t procedures to perform inference about the mean difference µd. These methods are called paired t procedures.

Examples of Matched Pairs Adopted twins into high (A) and low income(B) families; comparing Twin A IQ vs. Twin B IQ Multiplication Test Score with music playing vs. without music playing Test for Salmonella in 10 different eggs using two methods; compare measurements

Formulas Interval: 𝑥 𝑑𝑖𝑓𝑓 ±𝑡 ∙ 𝑠 𝑑𝑖𝑓𝑓 𝑛 𝑑𝑖𝑓𝑓 Significance Test: t = 𝑥 𝑑𝑖𝑓𝑓− 0 𝑠 𝑑𝑖𝑓𝑓 𝑛 𝑑𝑖𝑓𝑓

Which twin is smarter? A researcher studied a random sample of identical twins who had been separate and adopted at birth. In each case, one twin (twin A) was adopted by a high-income family and the other twin (twin B) was adopted by a low –income family. Both twins were given an IQ test as adults. Construct and interpret a 95% confidence interval for the true mean different in IQ score among twins raised in high-income and low-income households. Pair 1 2 3 4 5 6 7 8 9 10 11 12 Twin A 128 104 108 100 116 105 103 124 114 112 Twin B 120 99 94 111 97 113

Which twin is smarter? Pair 1 2 3 4 5 6 7 8 9 10 11 12 Twin A 128 104 108 100 116 105 103 124 114 112 Twin B 120 99 94 111 97 113 Diff (A- B) -1

Parameter: µ diff = the true mean difference (Twin A- B) in IQ score for pairs of identical twins raised in sperate households Assess Conditions: Random: SRS, stated Normal: Based on the dot plot, there are no obvious outliers, so we can consider the sample reasonably normal. Independent: Assume that 12 is less than 10% of all pairs of twins raised in separate households.

Name Interval: t-interval for difference Interval: Conclude: We are 95% confidence that the interval from 3.338 to 8.32867captures the true mean population difference (high - low income) in IQ scores among pairs of identical twins raised in separate homes.

Caffeine: Paired Data Researchers designed an experiment to study the effects of caffeine withdrawal. They recruited 11 volunteers who were diagnosed as being caffeine dependent to serve as subjects. Each subject was barred from coffee, colas, and other substances with caffeine for the duration of the experiment. During one two-day period, subjects took capsules containing their normal caffeine intake. During another two-day period, they took placebo capsules. The order in which subjects took caffeine and the placebo was randomized. At the end of each two-day period, a test for depression was given to all 11 subjects. Researchers wanted to know whether being deprived of caffeine would lead to an increase in depression. A higher value equals higher levels of depression. Data on next slide.

Results of a caffeine deprivation study Subject Depression (caffeine) Depression (placebo) Difference (placebo – caffeine) 1 5 16 11 2 23 18 3 4 7 8 14 6 24 19 9 15 13 10 12 - 1

State Parameters & State Hypothesis: If caffeine deprivation has no effect on depression, then we would expect the actual mean difference in depression scores to be 0. Parameter: µd = the true mean difference (placebo – caffeine) in depression score. Hypotheses: H0: µd = 0 Ha: µd > 0 Since no significance level is given, we’ll use α = 0.05.

Assess Conditions: Random researchers randomly assigned the treatment order— placebo then caffeine, caffeine then placebo—to the subjects. Normal We don’t know whether the actual distribution of difference in depression scores (placebo - caffeine) is Normal. So, with such a small sample size (n = 11), we need to examine the data Independent We aren’t sampling, so it isn’t necessary to check the 10% condition. We will assume that the changes in depression scores for individual subjects are independent. This is reasonable if the experiment is conducted properly. The boxplot shows some right- skewness but no outliers; with no outliers or strong skewness, the t procedures are reasonable to use.

Name Test, Test Statistic (Calculate) and Obtain P-value  

Make Decision & State Conclusion: Make Decision: Since the P-value of 0.0027 is much less than α = 0.05, we have convincing evidence to reject H0: µd = 0. State Conclusion: We can therefore conclude that depriving these caffeine-dependent subjects of caffeine caused* an average increase in depression scores. *Since the data came from a well-designed experiment we can use the word “caused”