Changing Incidence of Serum 25-Hydroxyvitamin D Values Above 50 ng/mL: A 10-Year Population-Based Study  Daniel V. Dudenkov, MD, Barbara P. Yawn, MD, MS, FAAFP, Sara S. Oberhelman, MD, Philip R. Fischer, MD, Ravinder J. Singh, PhD, Stephen S. Cha, MS, Julie A. Maxson, BA, Stephanie M. Quigg, MS, Tom D. Thacher, MD  Mayo Clinic Proceedings  Volume 90, Issue 5, Pages 577-586 (May 2015) DOI: 10.1016/j.mayocp.2015.02.012 Copyright © 2015 Mayo Foundation for Medical Education and Research Terms and Conditions

Figure 1 Age- and sex-adjusted incidence trend (per 100,000 person-years) of 25-hydroxyvitamin D (25(OH)D) values >50 ng/mL from 2002 to 2011: (A) age group (0-18 group is the reference for P values) and (B) sex (men are the reference for P values). Mayo Clinic Proceedings 2015 90, 577-586DOI: (10.1016/j.mayocp.2015.02.012) Copyright © 2015 Mayo Foundation for Medical Education and Research Terms and Conditions

Figure 2 Age- and sex-adjusted incidence trend (per 100,000 person-years) of elevated vitamin D levels from 2002 to 2011 in Olmsted County, Minnesota, for patients with 25-hydroxyvitamin D (25(OH)D) values ≥80 and ≥100 ng/mL. P values represent the significance of the trend. Mayo Clinic Proceedings 2015 90, 577-586DOI: (10.1016/j.mayocp.2015.02.012) Copyright © 2015 Mayo Foundation for Medical Education and Research Terms and Conditions

Figure 3 Bivariate plots of serum calcium, 25-hydroxyvitamin D (25(OH)D), and parathyroid hormone (PTH) data of patients with 25(OH)D values >50 ng/mL. A, Relation of total calcium to 25(OH)D concentrations (n=1035). B, Relation of PTH to total calcium (n=95). Mayo Clinic Proceedings 2015 90, 577-586DOI: (10.1016/j.mayocp.2015.02.012) Copyright © 2015 Mayo Foundation for Medical Education and Research Terms and Conditions