Intrathecal lidocaine elevates prostaglandin E2 levels in cerebrospinal fluid: a microdialysis study in freely moving rats† V. Umbrain, L. Shi, M.-H.

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Intrathecal lidocaine elevates prostaglandin E2 levels in cerebrospinal fluid: a microdialysis study in freely moving rats† V. Umbrain, L. Shi, M.-H. Lauwers, I. Smolders, Y. Michotte, F. Camu British Journal of Anaesthesia Volume 101, Issue 5, Pages 716-722 (November 2008) DOI: 10.1093/bja/aen243 Copyright © 2008 British Journal of Anaesthesia Terms and Conditions

Fig 1 PGE2 concentrations in CSF dialysates after i.t. injection of saline (50 μl), 400 μg lidocaine (20 μl), or 1000 μg lidocaine (50 μl). Data are reported as mean (sem) per cent change of baseline. *P<0.05 vs baseline for Lido 1000 μg; **P<0.05 for Lido 400 μg. British Journal of Anaesthesia 2008 101, 716-722DOI: (10.1093/bja/aen243) Copyright © 2008 British Journal of Anaesthesia Terms and Conditions

Fig 2 Effect of pretreatment with i.t. MK801 (5 μg) before i.t lidocaine 400 μg on dialysate CSF PGE2 concentrations. Data are reported as mean (sem) per cent change of baseline. *P<0.05 vs baseline. British Journal of Anaesthesia 2008 101, 716-722DOI: (10.1093/bja/aen243) Copyright © 2008 British Journal of Anaesthesia Terms and Conditions

Fig 3 Effect of pretreatment with i.t. SC76309A (10 μg) before i.t. lidocaine 400 μg on dialysate CSF PGE2 concentrations. Data are reported as mean (sem) per cent change of baseline. *P<0.05 vs baseline. British Journal of Anaesthesia 2008 101, 716-722DOI: (10.1093/bja/aen243) Copyright © 2008 British Journal of Anaesthesia Terms and Conditions

Fig 4 Radiant heat sensitivity and Von Frey testing after i.t. lidocaine 400 μg. Data are reported as mean (sem) per cent change of baseline. *P<0.05 vs baseline. British Journal of Anaesthesia 2008 101, 716-722DOI: (10.1093/bja/aen243) Copyright © 2008 British Journal of Anaesthesia Terms and Conditions