Figure 6 Metabolism of pterins

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Date of download: 9/19/2016 Copyright © The American College of Cardiology. All rights reserved. From: Coronary endothelial dysfunction in the insulin-resistant.

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Figure 6 Metabolism of pterins Figure 6 | Metabolism of pterins. Tetrahydrobiopterin can be generated from GTP through a series of enzymatic steps. Tetrahydrobiopterin is a co-factor in a number of cellular reactions, and is oxidized to quinonoid dihydrobiopterin, which can be recycled by dihydropteridine reductase (DHPR), and to dihydrobiopterin, which is recycled by dihydrofolate reductase (DHFR). The latter enzyme is antagonized by methotrexate). Brown, P. M. et al. (2016) Mechanism of action of methotrexate in rheumatoid arthritis, and the search for biomarkers Nat. Rev. Rheumatol. doi:10.1038/nrrheum.2016.175