Non-steroidal anti-inflammatory drugs in the oncological surgical population: beneficial or harmful? A systematic review of the literature J.P. Cata,

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Non-steroidal anti-inflammatory drugs in the oncological surgical population: beneficial or harmful? A systematic review of the literature J.P. Cata, C.E. Guerra, G.J. Chang, V. Gottumukkala, G.P. Joshi British Journal of Anaesthesia Volume 119, Issue 4, Pages 750-764 (October 2017) DOI: 10.1093/bja/aex225 Copyright © 2017 The Author(s) Terms and Conditions

Fig 1 The PRISMA flow diagram summarizes the literature search and selection process of relevant manuscripts on non-steroidal anti-inflammatory drugs (NSAIDs) and anastomotic leaks. British Journal of Anaesthesia 2017 119, 750-764DOI: (10.1093/bja/aex225) Copyright © 2017 The Author(s) Terms and Conditions

Fig 2 The PRISMA flow diagram summarizes the literature search and selection process of relevant manuscripts on non-steroidal anti-inflammatory drugs (NSAIDs) and cancer recurrence. British Journal of Anaesthesia 2017 119, 750-764DOI: (10.1093/bja/aex225) Copyright © 2017 The Author(s) Terms and Conditions

Fig 3 This figure depicts potential mechanisms behind NSAIDs-induced anastomotic leaks. NSAIDs, non-steroidal anti-inflammatory drugs; COX-2, cyclooxygenase-2 enzyme; (+), favouring healing effect; (-), inhibitory healing effect. British Journal of Anaesthesia 2017 119, 750-764DOI: (10.1093/bja/aex225) Copyright © 2017 The Author(s) Terms and Conditions

Fig 4 This figure illustrates the postulated mechanisms by which non-steroidal anti-inflammatory drugs (NSAIDs) administered in the perioperative period may reduce cancer recurrence. British Journal of Anaesthesia 2017 119, 750-764DOI: (10.1093/bja/aex225) Copyright © 2017 The Author(s) Terms and Conditions