Estimation of mechanical properties of articular cartilage with MRI – dGEMRIC, T2 and T1 imaging in different species with variable stages of maturation

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Presentation transcript:

Estimation of mechanical properties of articular cartilage with MRI – dGEMRIC, T2 and T1 imaging in different species with variable stages of maturation M.J. Nissi, B.Sc., J. Rieppo, B.M., J. Töyräs, Ph.D., M.S. Laasanen, Ph.D., I. Kiviranta, M.D., Ph.D., M.T. Nieminen, Ph.D., J.S. Jurvelin, Ph.D. Osteoarthritis and Cartilage Volume 15, Issue 10, Pages 1141-1148 (October 2007) DOI: 10.1016/j.joca.2007.03.018 Copyright © 2007 Osteoarthritis Research Society International Terms and Conditions

Fig. 1 Representative T2, T1 and T1Gd maps for all species, human (a), bovine (b) and porcine (c). All images are in the same scale, the scale bar is 1mm. Color bar gives the millisecond-scale for T1, T1Gd and T2 parameters. Osteoarthritis and Cartilage 2007 15, 1141-1148DOI: (10.1016/j.joca.2007.03.018) Copyright © 2007 Osteoarthritis Research Society International Terms and Conditions

Fig. 2 Group mean profiles for T2 (a), T1Gd (b) and T1 (c) for human (*), bovine (□) and porcine (○) samples, respectively. For all figures, the depth is normalized from articular surface to the subchondral bone. Osteoarthritis and Cartilage 2007 15, 1141-1148DOI: (10.1016/j.joca.2007.03.018) Copyright © 2007 Osteoarthritis Research Society International Terms and Conditions

Fig. 3 Correlation plots for T2 vs dynamic stiffness (Edyn) and T1 vs equilibrium stiffness (Eeq) in all species combined. Different species are denoted with symbols (* – human, □ – bovine and ○ – porcine). Osteoarthritis and Cartilage 2007 15, 1141-1148DOI: (10.1016/j.joca.2007.03.018) Copyright © 2007 Osteoarthritis Research Society International Terms and Conditions

Fig. 4 Average Gd-DTPA2− concentration (mM) for each species calculated using four different values for native T1 relaxation time: (black) single T1 value for cartilage, (dark gray) spatially measured T1 value for each sample, (light gray) average T1 value for each sample and (white) average T1 value for each species. Osteoarthritis and Cartilage 2007 15, 1141-1148DOI: (10.1016/j.joca.2007.03.018) Copyright © 2007 Osteoarthritis Research Society International Terms and Conditions