Synthetic Biology Looks Good on Paper Allison J. Lopatkin, Lingchong You  Cell  Volume 159, Issue 4, Pages 718-720 (November 2014) DOI: 10.1016/j.cell.2014.10.003 Copyright © 2014 Elsevier Inc. Terms and Conditions

Figure 1 Integration of Synthetic Gene Circuits with Paper Microfluidics (A) Cell-free systems with paper microfluidics. Cell extracts containing gene circuits are freeze-dried, embedded on filter paper, and later reconstituted to realize diverse functions. These functions range from inducible gene expression to sophisticated input/output functions. Panel shows a typical RNA-based toehold switch, which is used as the core module for an array of biosensors to detect diverse targets, including antibiotic resistance genes and Ebola viruses. (B) Multiscale, hybrid systems can be built by integrating cell-free and cell-based systems, as well as microencapsulation and paper-fluidics. Such systems can enable division of labor between different components in carrying out sophisticated sensing, processing, and actuating tasks. Cell 2014 159, 718-720DOI: (10.1016/j.cell.2014.10.003) Copyright © 2014 Elsevier Inc. Terms and Conditions