Order from Chaos: Single Cell Reprogramming in Two Phases

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Presentation transcript:

Order from Chaos: Single Cell Reprogramming in Two Phases Guangjin Pan, Duanqing Pei Cell Stem Cell Volume 11, Issue 4, Pages 445-447 (October 2012) DOI: 10.1016/j.stem.2012.09.004 Copyright © 2012 Elsevier Inc. Terms and Conditions

Figure 1 Schematic View of Reprogramming Models and Phases (A) Two models exist to explain the reprogramming of somatic cells to pluripotent ones. SCNT is thought to reprogram by a deterministic mechanism (top). SCNT is known to be fast. The generation of iPSCs is thought to be stochastic (bottom). The process is lengthy and inefficient. A combined model may have both stochastic and deterministic phases (the sliding slope). (B) The likely cellular events of reprogramming as revealed by single cell analysis. Cell Stem Cell 2012 11, 445-447DOI: (10.1016/j.stem.2012.09.004) Copyright © 2012 Elsevier Inc. Terms and Conditions