P.J. Fanning, C.M. Raskett, N.H. Farina, D.C. Ayers, J.B. Lian

Slides:

Advertisements

Similar presentations

Full-thickness cartilage defects repaired by human induced pluripotent stem cells (IPSCS)-derived mesenchymal stem cells and plga scaffolds D. Shi, X.

Advertisements

Ability of T2 mapping to evaluate cartilage repair after allogenic chondrocyte implantation for osteochondral lesion J. Endo, A. Watanabe, T. Sasyo,

Next-generation Sequencing Identifies Articular Cartilage and Subchondral Bone Mirnas after ESWT on Early Osteoarthritis Knee C.-J. Wang, J.-H. Cheng,

A. Bhave, M. Mont, M. Chugthai, R. Starr Osteoarthritis and Cartilage

R. Takeuchi, H. Ishikawa, T. Kuniya, A. Nakazawa

S. Gavard Osteoarthritis and Cartilage

Prospective economic evaluation of the costs for medications and nutraceuticals in knee osteoarthritis M. Chung, N. Zhao, J.B. Wong, C. Wang Osteoarthritis.

Bone shape does not cause OA – But OA does change bone shape; a study on data from 4654 knees from the Osteoarthritis Initiative M.A. Bowes, C.B. Wolstenholme,

Does a yoga-strengthening program for women with knee osteoarthritis have an effect on gait patterns? An investigation with principal components analysis

Role of endothelin-1 in endochondral ossification and osteoarthritis

Automatic cartilage segmentation and measurement for diagnosis of OA using 3D box and Gaussian filters X. Cui, S. Li, M. Yu, H. Kim, K.-S. Kwack, B.-H.

Mineralization of meniscal enthesis in osteoarthritic knees

Effect of self assembled peptide-mesenchymal stem cell complex on delaying the progression of osteoarthritis S. Kim, S. Lee, Y. Jung, J. Kim, S. Kim

G. Venne, S. Pang, Y. Tse, R. Ellis Osteoarthritis and Cartilage

Comparison of the Usefulness of Laser-induced Photoacoustic Measurement & Magnetic Resonance Imaging (T2 Mapping, Diffusion Tensor Imaging) for Assessing.

Z. Zhang, W. Liao, Z. Zhang, X. Duan, C. Hou

Replicability of recommended exercise interventions for knee osteoarthritis: a descriptive systematic review of current clinical guidelines and recommendations

Damage to The Extracellular Matrix (ECM) in Articular Cartilage is Observed via Changes in The T2–T2 Exchange Rates Between Fluid in The Pore Space and.

The effect of conditional macrophage depletion on development of injury-induced knee OA in obese transgenic MAFIA mice C.-L. Wu, J. McNeill, K. Goon,

P. Yuan, X. Zhang, W. Yang, W. Kang, B. Yang, J. li, B. Chen, X. Li, B

Association of ultrasound-defined structural changes with regional and diffuse knee pain patterns – Oulu Knee Osteoarthritis study J. Podlipská, P. Kaukinen,

R. Nakamura, N. Komatsu, K. Fujita, H. Nishimura, Y. Katsuki

Anti-inflammatory Properties of SM04690, a Small Molecule Inhibitor of the Wnt Pathway as a Potential Treatment for Knee Osteoarthritis V. Deshmukh,

Role of periostin and discoidin domain receptor-1 (DDR1) in the regulation of cartilage degeneration and expression of MMP-13 M. Attur, Q. Yang, T. Kirsch,

Role of TCF4 in signaling crosstalk with NFκB in human chondrocytes

Two different knee braces alter patella position: a moving image analysis using weight bearing magnetic resonance imaging M.J. Callaghan, N.D. Reeves,

The influence of early osteoarthritic collagen network de-structuring in articular cartilage on the tissue stiffness and swelling properties M. Nickien,

Mice with global deletion of mitogen inducible gene 6 display rapid and severe cartilage and subchondral bone damage after ligament and meniscus injury

A new lipid formulation of low dose (1200mg) ibuprofen is non-inferior to high dose (2400mg) standard ibuprofen capsules in managing episodic knee pain.

Y. Levy, A. Hasegawa, S. Patil, M. Lotz, D. D'Lima

Effect of soft braces on pain and physical function in patients with knee osteoarthritis: systematic review with meta-analyses T. Cudejko, M. van der.

M.N. Khan, M.Y. Ansari, T.M. Haqqi Osteoarthritis and Cartilage

A randomised controlled trial to investigate walking 6,000 steps per day on pain and function in knee osteoarthritis progression: the walkout study M.S.

M.L. Roemhildt, A.E. Gauthier Osteoarthritis and Cartilage

Differential response of placebo treatments in osteoarthritis trials: a systematic review and network meta-analysis R.R. Bannuru, C.H. Schmid, M.C. Sullivan,

Individuals with accelerated knee osteoarthritis have greater pain and functional impairments than individuals with common knee osteoarthritis: Data from.

Structural Damage of the Thumb Base in Patients With Hand Osteoarthritis, Assessment by Magnetic Resonance Imaging Compared to Standard Radiography S.

Emerging role of endothelin receptor type B in regulating chondrogenic and hypertrophic changes of human mesenchymal stem cells M. Au, M. Zhu, W.-J.

Comparing clinical outcomes of exercise intervetions according to the American college of sports medicine guidelines for strength training to other types.

Immediate effects of a varus unloader brace on lateral knee osteoarthritis after anterior cruciate ligament reconstruction during stair ascent and stair.

Early intervention to prevent cartilage degeneration by administration of anti-vegf antibody in rabbit model T. Nagai, M. Sato, T. Kutsuna, T. Ukai,

Z. Huang, T. Stabler, F. Pei, V. Kraus Osteoarthritis and Cartilage

Acute influences of draw-in maneuver for knee adduction moment and hip and trunk muscle activities during a person's manner of walking S. Ota, H. Ohko,

Damps provide a link between joint tissue damage and pain through direct activation of TLR4 expressed by sensory neurons R.E. Miller, P.B. Tran, S. Ishihara,

A peptide temporally enhanced chondrogenesis of mesenchymal stem cells

Total knee replacement followed by a non-surgical treatment program reduce localized and spreading pain sensitization – A pre-defined ancillary analysis.

Evidence for bone mineral density and bone resorption in middle and elderly women with knee osteoarthritis in Shanghai: a cross sectional study Q. Xiaofeng

Walking with increased foot progression angle can reduce joint compression in individuals with knee OA K. Manal, T.S. Buchanan Osteoarthritis and Cartilage

Monocyte chemoattractant protein 1 induced chondrocytes degeneration and cartilage degradation in osteoarthritis X. yuankun, K. Yan, W. Bin, L. Jian-Hao

Individuals with severe knee OA are at increased risk of all-cause and cardiovascular disease-specific mortality: The johnston county osteoarthritis project

Subjects with severe knee osteoarthritis reduce medio-lateral forces during gait at the expense of compressive knee contact forces S. Meireles, F. De.

Multivariate pattern analysis of physical activity and cartilage health: data from the osteoarthritis initiative E. Halilaj, T.J. Hastie, G.E. Gold,

R. O. Peterson, S. R. Hoy, L. M. Vucetich, J. A. Vucetich, V. B

Leptin signaling and body weight are independent mediators of spontaneous knee osteoarthritis in female rats J. Hudson, M. West, Y. Fu, T. Griffin Osteoarthritis.

Location-specific hip joint space width for progression of hip osteoarthritis: predictive validity and responsiveness of a new computerized measure C.

Imaging biomarker with T1 and T2 mappings in osteoarthritis – In vivo human articular cartilage study C. Yan, C. Wong, T. Li, N. Gong, Q. Chan, K. Chiu

The effect of quadriceps-strengthening exercise on quadriceps and knee biomichanics during walking in adults with knee osteoarthritis: a randomized controlled.

How does lower leg alignment differ between soccer players, other athletes and non- athletic controls? W. colyn, R. Agricola, N. Arnout, J. Verhaar, J.

CD14 deficiency dampens osteoclastogenesis and alters bone remodeling in a murine model of osteoarthritis C. Zhou, V. Nguyen, R. Smalley, N. Sambamurthy,

Knee kinematic and kinetic modifications under body weight unloading during overground walking at a constant speed A.G. Fischer, E.M. Debbi, A. Wolf

Amyloid micronetworks for cartilage repair

Biomechanical knee cartilage analysis in young professional soccer players by a T2 mapping unloading algorithm G.H. Welsch, L. Waldenmeier, C. Evers,

Discovery of a small molecule inhibitor of the Wnt pathway (SM04690) as a potential disease modifying treatment for knee osteoarthritis J.D. Hood, V.

Quadriceps/Hamstrings co-activation during gait in individuals with anterior cruciate ligament reconstruction T. Blackburn, B. Pietrosimone, J. Goodwin,

E. M. Debbi, B. Bernfeld, E. Gray, M. Salai, Y. Levy, A. Gold, R

E. M. Debbi, B. Bernfeld, M. Falah, A. Greental, A. Sigal, R. Debi, A

Hypertrophy and structural alterations in tibiofemoral articular cartilage 6-24 months after anterior cruciate ligament reconstruction E. Thorhauer,

A. Carlson, B. Bothner, R. June Osteoarthritis and Cartilage

General Information Osteoarthritis and Cartilage

Long-term effects of vitamin d supplementation and maintaining vitamin d sufficiency on knee osteoarthritis over 5 years B. Antony, S. Zheng, J. Burgess,

Presentation transcript:

Micro-RNA Regulated Alterations in EGF and TGFB Signaling Pathways in Experimental Osteoarthritis P.J. Fanning, C.M. Raskett, N.H. Farina, D.C. Ayers, J.B. Lian Osteoarthritis and Cartilage Volume 25, Pages S288-S289 (April 2017) DOI: 10.1016/j.joca.2017.02.485 Copyright © 2017 Terms and Conditions

Figure 1: Analysis of 202 miRNAs differentially expressed 3-fold in OA vs. non-OA knee osteochondral samples. A). Principal component analysis (PCA) reveals 4 distinct clusters of expression patterns. B0. Average expression pattem of miRNAs within each cluster (I–IV) fordays 0, 4, 7, 14, 21 & 28, post-OA-inducing surgery. C). Hierarchical clustering: analysis of each PCA cluster according to post-operative day. Osteoarthritis and Cartilage 2017 25, S288-S289DOI: (10.1016/j.joca.2017.02.485) Copyright © 2017 Terms and Conditions

Osteoarthritis and Cartilage 2017 25, S288-S289DOI: (10. 1016/j. joca Copyright © 2017 Terms and Conditions