Nikole J. Byrne et al. BTS 2017;j.jacbts

Slides:

Advertisements

Similar presentations

Parameter WT Rnd3+/- n 7 Body weight (g) 25.59± ±2.11

Advertisements

Diminished Left Ventricular Dyssynchrony and Impact of Resynchronization in Failing Hearts With Right Versus Left Bundle Branch Block J Am Coll Cardiol.

Echocardiographic modalities for evaluation and risk stratification of heart failure patients. 3D indicates 3-dimensional; EF, ejection fraction; LA, left.

Choline Diet and Its Gut Microbe–Derived Metabolite, Trimethylamine N-Oxide, Exacerbate Pressure Overload–Induced Heart FailureCLINICAL PERSPECTIVE by.

Bindiya Patel et al. BTS 2018;3:

Metabolic effects of K107R and rosiglitazone treatment.

Johannes Steiner et al. JACC 2017;70:

Fig. 4. Biomechanical properties of treated tibiae.

Mirnela Byku, and Douglas L. Mann BTS 2016;1:95-106

Fig. 2. Vascular inflammation blocks perivascular adipocyte differentiation through paracrine signals. Vascular inflammation blocks perivascular adipocyte.

Fig. 4. Perampanel ameliorates behavioral deficits in mice expressing the Thorase variants. Perampanel ameliorates behavioral deficits in mice expressing.

Bindiya Patel et al. BTS 2018;j.jacbts

Sleep/wake phenotype of S551D mutant mice.

Cardiac Fibrosis at 18 Weeks Post TAC (A) Representative images (original magnification ×20) of Picrosirius red-stained cardiac tissue sections from HF +

Rachel Truitt et al. BTS 2018;3:

Hironori Hara et al. BTS 2018;3:

Heather M. Wilson et al. BTS 2018;3:

Mohamed A. Saleh et al. BTS 2016;1:

Volume 22, Issue 6, Pages (December 2015)

Bindiya Patel et al. BTS 2018;j.jacbts

Romain Gallet et al. BTS 2016;1:14-28

Romain Gallet et al. BTS 2016;1:14-28

Mohamed A. Saleh et al. BTS 2016;1:

Renal Fibrosis and Plasma Creatinine Levels at 18 Weeks Post TAC (A) Plasma creatinine levels. (B) Representative images (original magnification ×20) of.

LV Structure, Function, and Circulating BNP Levels at 18 Weeks Post TAC (A) (B) LVEDD and LVESD (mm) throughout the experimental protocol. (C) Percent.

Helena M. Viola et al. BTS 2018;3:

Therapeutic activity of gal‐encapsulated cytotoxic drugs on tumor xenografts Therapeutic activity of gal‐encapsulated cytotoxic drugs on tumor xenografts.

J. Craig Hartman et al. BTS 2018;3:

Supplementary Figure 5: Effect of S48168 on normalized organ and skeletal muscle weights after 12 weeks of treatment for all the experimental groups from.

Aortic Vasorelaxation at 18 Weeks Post TAC Freshly isolated thoracic aortic rings were allowed to equilibrate, and pre-contracted with 1 μM phenylephrine.

Nikole J. Byrne et al. BTS 2017;j.jacbts

Limiting neutrophilic inflammation during active phase (ZT13) reduces MI damage Limiting neutrophilic inflammation during active phase (ZT13) reduces MI.

Experimental Compounds and Experimental Protocol (A) Chemical structures of JK-1 and control. Hydrolysis of JK-1 yields H2S and the chemical backbone of.

N-terminal pro-B-type natriuretic peptide (NT-proBNP) levels for patients undergoing surgical aortic valve replacement (SAVR) (A), patients undergoing.

AhR activation reduces lung DC gene and surface expression of DC-SIGN.

Glucose, insulin, and AGE levels during an OGC before and after RT

PMPs survive STZ cytotoxicity and produce larger colonies with a higher yield of insulin+ progeny. PMPs survive STZ cytotoxicity and produce larger colonies.

Measurement of insulin release from islets evoked by glucose, diazoxide, and high K+. Measurement of insulin release from islets evoked by glucose, diazoxide,

William T. Abraham et al. JCHF 2018;j.jchf

Phosphorylated CREB levels were assessed in the hippocampus at 20 min after cue and contextual fear conditioning. Phosphorylated CREB levels were assessed.

Treatment of ob/ob mice with TTR-ASOs improves insulin sensitivity.

OTU and family-level changes in murine gut as a result of acarbose feeding on a high-starch diet. OTU and family-level changes in murine gut as a result.

Percentage distribution of ESC HF subtypes and no cardiac dysfunction (no dysf, n=38) among all 370 included patients, where HFvhd is HF due to valvular.

Chronic SSRI treatment rescued lOFC hyperactivity in QNP-treated mice.

Pioglitazone administration acutely inhibits insulin secretion and increases insulin clearance in Wistar rats. Pioglitazone administration acutely inhibits.

Fig. 5 Treatment with BMS (PO BID) protects from wasting and colitis in two SCID mouse models. Treatment with BMS (PO BID) protects from.

CRISPRa induction of Bdnf mRNA increases spike and burst frequency in hippocampal neurons cultured on microelectrode arrays (MEAs). CRISPRa induction of.

FMRP S499 rephosphorylation kinetics after CX-4945 treatment and washout mirrors a known CK2 target. FMRP S499 rephosphorylation kinetics after CX-4945.

The dopamine (DA) response to cocaine infusion in the NAc in constitutive p11 KO mice is restored by nicotinic or muscarinic receptor stimulation in the.

NicA2-J1 prevents nicotine addiction–like behavior during withdrawal

Intra-amygdala MPEP is analgesic during bladder distention.

Fig. 6. Prolonged miR overexpression in the adult heart reduces fibrotic scar size but compromises cardiac function after MI. Prolonged miR

Cytokine expression in the ileum and colon.

Treadmill Exercise Capacity at 18 Weeks Post TAC Exercise capacity was evaluated in all study groups at 18 weeks following TAC surgery. (A) Duration (min)

Pre- and post-vorinostat values of ER-related gene expression using the Oncotype DX 21-gene assay. Pre- and post-vorinostat values of ER-related gene expression.

Fig. 1. The HCN channel blocker ivabradine (IVA) is analgesic in a mouse model of type 1 diabetes. The HCN channel blocker ivabradine (IVA) is analgesic.

Michael A. Makara et al. BTS 2018;3:

A, change in Ki-67 expression (percent of cells staining positive) over the course of the intervention. A, change in Ki-67 expression (percent of cells.

Fig. 3 Echocardiographic analyses of cardiac function.

HMQ1611 inhibited breast tumor growth in mice.

Subodh Verma et al. BTS 2018;3:

Fig. 7 Heart-specific OMA1 down-regulation protects from hypertrophy induced by TAC. Heart-specific OMA1 down-regulation protects from hypertrophy induced.

Renal Norepinephrine Content, Circulating Renin, Ang II, and Aldosterone Levels at 18 Weeks Post TAC (A) Renal tissue norepinephrine content (ng/ml). (B)

Protective effects of grape PP supplementation on HFrD-induced oxidative stress. Protective effects of grape PP supplementation on HFrD-induced oxidative.

Molecular Therapy - Nucleic Acids

The effect of TGFβ on the post-RT increase of Tregs in tumors.

Fig. 6. Combinatorial VCPI and OV M1 treatment is efficacious in vivo and ex vivo. Combinatorial VCPI and OV M1 treatment is efficacious in vivo and ex.

Günaj Rakipovski et al. BTS 2018;3:

Alp1 induces ASM contraction.

Fig. 2. In vivo local CD25-targeted NIR-PIT induces regression of treated LL/2-luc tumors. In vivo local CD25-targeted NIR-PIT induces regression of treated.

Presentation transcript:

Nikole J. Byrne et al. BTS 2017;j.jacbts.2017.07.003 Empagliflozin Treatment Prevents Worsening of Cardiac Function in Mice With Heart Failure Experimental design of Empa treatment in mice in which HF was induced using TAC. (A) Urine glucose levels are shown for vehicle-treated and Empa-treated HF mice (B) (n = 3). Ejection fraction (%EF) of vehicle-treated (C) and Empa-treated (D) mice with HF and expressed as change from baseline (E) and pre and post gavage (F) based on echocardiographic assessment (n = 10 to 13). Results are mean ± SEM. Wilcoxon signed rank test was used to evaluate pre- versus post-gavage data (C, D). Comparisons between groups were performed using Mann-Whitney U test (E) and repeated measures 2-way ANOVA followed by Sidak multiple comparisons tests (F). **p < 0.01 versus baseline. Empa = empagliflozin; HF = heart failure; TAC = transverse aortic constriction. Nikole J. Byrne et al. BTS 2017;j.jacbts.2017.07.003 2017 The Authors