Volume 22, Issue 3, Pages 159-163 (September 2015) The influence of ovariectomy on anti-convulsant effect of pioglitazone in mice  Leila Moezi, Mahsa Hassanipour, Meysam Zaeri, Hassan Ghorbani, Hamed Shafaroodi  Pathophysiology  Volume 22, Issue 3, Pages 159-163 (September 2015) DOI: 10.1016/j.pathophys.2015.06.002 Copyright © 2015 Elsevier B.V. Terms and Conditions

Fig. 1 The effect of chronic treatment with different doses of pioglitazone onthe intravenous pentylenetetrazole-induced clonic seizure threshold in female mice. Pioglitazonewas administered 10 days by gavageand each group consisted of 7 mice. Data are expressed as mean±S.E.M. *P<0.05 and **P<0.01 compared to vehicle groupand ##P<0.01 compared to pioglitazone (5mg/kg). Pathophysiology 2015 22, 159-163DOI: (10.1016/j.pathophys.2015.06.002) Copyright © 2015 Elsevier B.V. Terms and Conditions

Fig. 2 The effect of chronic treatment with different doses of pioglitazone onthe intraperitoneal pentylenetetrazole-induced clonic seizure latency in female mice. Pioglitazonewas administered 10 days by gavage. The number of mice in each group has been shown in Table 1. Data are expressed as mean±S.E.M. ***P<0.001 compared to vehicle group. Pathophysiology 2015 22, 159-163DOI: (10.1016/j.pathophys.2015.06.002) Copyright © 2015 Elsevier B.V. Terms and Conditions

Fig. 3 The influence of ovariectomy on anti-convulsant effect of pioglitazone inthe intravenous pentylenetetrazole-induced clonic seizure threshold of female mice. Pioglitazone administration started one day after ovariectomy and lasted 10 days. Data are expressed as mean±S.E.M. The number of mice in ovariectomized and non-ovariectomized groups was 6 and 7, respectively. **P<0.01 compared to vehicle group and ##P<0.01 and ###P<0.001 compared to non-ovariectomized pioglitazone-treated corresponding group. Pathophysiology 2015 22, 159-163DOI: (10.1016/j.pathophys.2015.06.002) Copyright © 2015 Elsevier B.V. Terms and Conditions

Fig. 4 The influence of ovariectomy on anti-convulsant effect of pioglitazone inthe intraperitoneal pentylenetetrazole-induced seizure model of female mice.Pioglitazone administration started one day after ovariectomy and lasted 10 days. The number of mice in each group has been shown in Table 2. Data are expressed as mean±S.E.M. ***P<0.001 compared to vehicle group and ##P<0.01 and ###P<0.001 compared to non-ovariectomized pioglitazone-treated corresponding group. Pathophysiology 2015 22, 159-163DOI: (10.1016/j.pathophys.2015.06.002) Copyright © 2015 Elsevier B.V. Terms and Conditions