Virus-specific serum antibody response of BALB/c mice to DNA prime followed by VRP boost. Virus-specific serum antibody response of BALB/c mice to DNA.

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Virus-specific serum antibody response of BALB/c mice to DNA prime followed by VRP boost. Virus-specific serum antibody response of BALB/c mice to DNA prime followed by VRP boost. IgG antibody titers against HK/Syd (1 μg HA ml−1) were measured by ELISA and are shown at day 21 of the quaternary response to the vaccine. Data are reported for the following numbers of mice in the various groups: for vector DNA plus PBS, n = 8; for vector DNA plus GFP-VRP, n = 15; for vector DNA plus HA-VRP, n = 15; for HA-DNA plus PBS, n = 10; for HA-DNA plus GFP-VRP, n = 17; and for HA-DNA plus HA-VRP, n = 18. An asterisk indicates a significant difference in titer for mice vaccinated with HA-DNA plus PBS and mice vaccinated with HA-DNA plus GFP-VRP compared to those for mice in groups inoculated with vector DNA plus PBS and vector DNA plus GFP-VRP (P < 0.01 by ANOVA). A double asterisk indicates a significant difference in titer for mice vaccinated with HA-DNA plus HA-VRP compared to those for all three groups of vector DNA-vaccinated mice (P < 0.01 by ANOVA). Victor C. Huber et al. Clin. Vaccine Immunol. 2006; doi:10.1128/CVI.00156-06