Reconciling Epigenetic Memory and Transcriptional Responsiveness Amanda G. Fisher, Michael P.H. Stumpf, Matthias Merkenschlager  Cell Systems  Volume 4, Issue 4, Pages 373-374 (April 2017) DOI: 10.1016/j.cels.2017.04.005 Copyright © 2017 Terms and Conditions

Figure 1 Spreading and Transmission of H3K27me3-Modified Chromatin (A) Histone H3K27 (orange circles with black rods) methylation of a nucleosome template (n1) is copied between adjacent nucleosomes in cis (n2) by the PRC2 complex; components within the complex provide both chromatin reader (blue) and writer (yellow) functions. (B) During DNA synthesis, new unmodified histones (black rods without orange circles) are incorporated and redistributed as the replication fork progresses, providing a fresh nucleosome template (pink) for PRC2-mediated methylation of H3K27. Cell Systems 2017 4, 373-374DOI: (10.1016/j.cels.2017.04.005) Copyright © 2017 Terms and Conditions