The Oncofetal Protein IMP3: A Useful Marker to Predict Poor Clinical Outcome in Neuroendocrine Tumors of the Lung Alessandro Del Gobbo, MD, Valentina.

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The Oncofetal Protein IMP3: A Useful Marker to Predict Poor Clinical Outcome in Neuroendocrine Tumors of the Lung Alessandro Del Gobbo, MD, Valentina Vaira, PhD, Elena Guerini Rocco, MD, Alessandro Palleschi, MD, Gaetano Bulfamante, MD, Dario Ricca, BS, Stefano Fiori, MD, Silvano Bosari, MD, Stefano Ferrero, MD Journal of Thoracic Oncology Volume 9, Issue 11, Pages 1656-1661 (November 2014) DOI: 10.1097/JTO.0000000000000316 Copyright © 2014 International Association for the Study of Lung Cancer Terms and Conditions

FIGURE 1 Cox proportional-hazards regression of IMP3-positive and -negative cases for disease-free survival (A, p = 0.0010) and overall survival (B, p = 0.0002). Journal of Thoracic Oncology 2014 9, 1656-1661DOI: (10.1097/JTO.0000000000000316) Copyright © 2014 International Association for the Study of Lung Cancer Terms and Conditions

FIGURE 2 Cox proportional-hazards regression of IMP3 and Ki67 values for atypical carcinoids: cases IMP3-negative and Ki67 < 4% are classified as “negative”, and cases IMP3-positive and Ki67 > 4% are classified as “positive” with a statistical significance regarding the overall survival (A, p = 0.04) and disease-free survival (B, p = 0.01). Journal of Thoracic Oncology 2014 9, 1656-1661DOI: (10.1097/JTO.0000000000000316) Copyright © 2014 International Association for the Study of Lung Cancer Terms and Conditions

FIGURE 3 IMP3 and Nanog brown, cytoplasmic (IMP3) and nuclear/cytoplasmic (Nanog) staining in a typical carcinoid (A and B, respectively), in an atypical carcinoid (C and D, respectively) and in a large cell neuroendocrine carcinomas (E and F, respectively). Regarding the Nanog staining, in this case of typical carcinoid it was scored as 1 + (B), in the case of atypical carcinoid as 3 + (D) and in the case of large cell neuroendocrine carcinomas as 2+ (TMA spot: 4×, insert: 20×). Journal of Thoracic Oncology 2014 9, 1656-1661DOI: (10.1097/JTO.0000000000000316) Copyright © 2014 International Association for the Study of Lung Cancer Terms and Conditions